Evidence map›Paper›PMID 39471501›Full record

ArticleThe American journal of tropical medicine and hygiene2025

Hypercalcemia and Acute Kidney Injury Associated with Disseminated Paracoccidioidomycosis.

Renan Gomes Mendes Diniz, Betina Nogueira Da Silva, Raoni De Oliveira Domingues-Da-Silva, Marcelo Arnone, Walter Belda Júnior, Elizabeth De Francesco Daher, Lucia Andrade

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In one paragraph

Article in The American journal of tropical medicine and hygiene, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

7 authors.

Renan Gomes Mendes DinizFaculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Betina Nogueira Da SilvaHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Raoni De Oliveira Domingues-Da-SilvaFaculdade de Medicina da Universidade Federal do Ceará, Fortaleza, Brazil.
Marcelo ArnoneHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Walter Belda JúniorHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Elizabeth De Francesco DaherFaculdade de Medicina da Universidade Federal do Ceará, Fortaleza, Brazil.
Lucia AndradeFaculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paracoccidioidomycosis is an acute to chronic systemic mycosis caused by the fungi Paracoccidioides. Hypercalcemia is a rare and not fully understood presentation of this infection. We present a case report of paracoccidioidomycosis associated with hypercalcemia and acute kidney injury (AKI) in an immunocompetent patient. An immunocompetent 30-year-old man from Brazil presented with papular erythematous-violaceous skin lesions, disseminated lymphadenopathy, pain in the left hypochondrium, fever with night sweats, and loss of 25 kilograms in 5 months. The result of a biopsy of the lesions was positive for Paracoccidioides brasiliensis. Laboratory findings were high total calcium and 1,25-dihydroxy vitamin D, with low parathyroid hormone, low albumin, and AKI. Computed tomography scans revealed splenic infarcts without bone lesions. Treatment was performed with methylprednisolone and liposomal amphotericin B. Calcium levels and kidney function normalized within 20 days of hospitalization. The patient was discharged 49 days after admission. A follow-up 6 months later revealed total clinical and serological remission.

Indexed as

Acute Kidney InjuryAntifungal AgentsHypercalcemiaParacoccidioidomycosisAdultAmphotericin BCalciumHumansMaleMethylprednisoloneParacoccidioidesAmphotericin BAntifungal AgentsCalciumliposomal amphotericin BMethylprednisolone

Identifiers

PMID39471501
PMCPMC11720778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.