ArticleAsian Pacific journal of cancer prevention : APJCP2024
Cytotoxic Effect of Stenotrophomonas maltophilia Isolated from Prostate and Bladder Cancer Patients in Iraq.
Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Identification and Evaluation of the Urinary Microbiota Associated With Bladder Cancer.Cancer innovation · 2025Article
- Investigating the Anticancer Properties of Bacterial Toxoid in Combination Vaccines.Asian Pacific journal of cancer prevention : APJCP · 2025Article
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3 authors.
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Abstract
objectiveThis study investigated the cytotoxic effects of Stenotrophomonas maltophilia on normal human cells.
methodsSeven isolates of S. maltophilia were obtained from 120 urine samples collected from prostate and bladder cancer patients, with diagnoses confirmed via Vitek. The cytotoxicity of these bacterial isolates was assessed on normal human fibrocyte cells (NHF) using various concentrations of bacterial filtrate (3.125, 6.25, 12.5, 25, 50, and 100 μg/ml).
resultsThe bacterial filtrate exhibited significant toxicity to NHF cells, with the highest cell death rate of 68% and the lowest optical density (OD) of 0.25 at a concentration of 100 μg/ml. The IC50 value, indicating the concentration at which 50% inhibition of cell viability occurred, was determined to be 49.35 μg/ml. Further research is necessary to explore the potential role of these bacterial isolates in promoting cancer through inflammation.
conclusionThe clinical isolates of S. maltophilia demonstrated substantial cytotoxic activity against normal human fibrocyte cells, leading to a notable reduction in both cell number and optical density, with the highest percentage of cell death observed. These findings suggest the need for further investigation into the specific toxins or enzymes involved, which could pave the way for future studies.
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