Evidence map›Paper›PMID 39471020›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2024

Human papillomavirus (HPV) and Epstein-Barr virus (EBV) in Penile Cancer in Thailand.

Sakkarn Sangkhamanon, Taksaporn Thongnuapad, Ukrit Rompsaithong, Pakorn Kiatsopit, Supanut Lumbiganon, Prin Twinprai, Jarin Chindaprasirt, Wichien Sirithanaphol

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Article in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Sakkarn SangkhamanonDepartment of Pathology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Taksaporn ThongnuapadDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Ukrit RompsaithongDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Pakorn KiatsopitDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Supanut LumbiganonDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Prin TwinpraiDepartment of Radiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Jarin ChindaprasirtDepartment of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.ORCID 0000-0002-0401-9812
Wichien SirithanapholDepartment of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman papillomavirus (HPV) and Epstein-Barr virus (EBV) are important etiological factors for several cancers. This study aimed to determine the prevalence of HPV and EBV infection in penile cancer.

methodsForty-three formalin-fixed paraffin-embedded penile cancer tissue samples were analyzed for the HPV-induced p16INK4A protein by immunohistochemistry and Epstein-Barr encoding region in situ hybridization. Demographic data and overall survival were analyzed.

resultsThe median age of patients was 59 years, ranging from 23 to 91 years old. Most of the tumors (86%) were located at the tip of the penis. HPV infection was positive in 12/43 (27.9%) patients. EBV infection was observed in 2/43 (4.6%) of cases and there was no co-infection detected in this cohort. Patients who had p16INK4A overexpression had a trend toward longer survival compared to those without; the median survival time of 104.4 vs 89 months, the hazard ratio of 0.48 (95% CI: 0.16-1.42, p = 0.173).

conclusionsOne-third of penile cancer patients were positive for HPV-induced p16INK4A expression and there was a trend toward better survival in HPV-positive patients. EBV infection was infrequent in penile cancer in Thailand.

Indexed as

Cyclin-Dependent Kinase Inhibitor p16Epstein-Barr Virus InfectionsHerpesvirus 4, HumanPapillomaviridaePapillomavirus InfectionsPenile NeoplasmsAdultAgedAged, 80 and overCarcinoma, Squamous CellFollow-Up StudiesHuman Papillomavirus VirusesHumansMaleMiddle AgedPrognosisCyclin-Dependent Kinase Inhibitor p16Epstein-Barr Virushuman papillomavirusP16Penile cancerPrevalence

Identifiers

PMID39471020
PMCPMC11711368

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.