Evidence map›Paper›PMID 39471001›Full record

SynthesisAsian Pacific journal of cancer prevention : APJCP2024

Multifaceted Role of Vitamin D in Breast Cancer: A Systematic Review of Genetic and Pathway-Based Mechanisms.

Sepideh Abdollahi, Mahsa Vahdat, Zahra Saeedirad, Zahra Mahmoudi, Mahdie Torkaman, Khadijeh Abbassi Mobarakeh, Masoomeh Alsadat Mirshafahi, Mohammad Keshavarz Mohammadian, Masoomeh Ataei Kachooei, Ghasem Azizi-Tabesh and 5 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Asian Pacific journal of cancer prevention : APJCP, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sepideh AbdollahiDepartment of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mahsa VahdatDepartment of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Zahra SaeediradDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zahra MahmoudiDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Mahdie TorkamanDepartment of Chemical Engineering, Science and Research Branch , Islamic Azad University ,Tehran Iran.
Khadijeh Abbassi MobarakehDepartment of Community Nutrition, Nutrition and Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Masoomeh Alsadat MirshafahiDepartment of Sport Physiology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
Mohammad Keshavarz MohammadianDepartment of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Masoomeh Ataei KachooeiFaculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Ghasem Azizi-TabeshGenomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ali Shamsi-GoushkiDepartment of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Maryam GholamalizadehCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Sara KhoshdoozGuilan University of Medical Sciences, Rasht, Iran.
Saeid DoaeiDepartment of Community Nutrition, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Mohammad PoorhosseiniGenomic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite advancements in breast cancer (BC) diagnosis and treatment, it continues to be a serious health concern among women due to its high incidence rate. Thus, prevention strategies in BC are essential. Some nutrients such as vitamin D may play a preventive role against BC through different genes which have a vital role in several pathways. These pathways include autophagy, tumorigenesis, apoptosis, immunity, and genome stability. This study aimed to review the role of vitamin D in BC via the network of vitamin D-regulated pathways.

methodsThis systematic review was conducted following PRISMA guidelines. PubMed, ScienceDirect, and Scopus were searched using a combination of MeSH terms and keywords related to molecular and cellular mechanisms of the effects of vitamin D on breast cancer. A total of 200 articles were initially found, from which 14 relevant studies were selected based on specific inclusion and exclusion criteria.

resultsExperimental studies have shown possible anti-carcinogenic effects of vitamin D-related genes due to their participation in regulating autophagy, tumorigenesis, apoptosis, immunity, and genome stability in normal and malignant breast cells. Moreover, vitamin D deficiency has the potential to create a supportive environment that promotes proangiogenic processes, tumor cell dissemination, metastasis, and establishment at secondary sites.

conclusionVitamin D may have systematic roles against BC in humans through various interactions with different genes, which have roles in different and important pathways as underlying mechanisms in the pathophysiology of BC. More broadly, research is also needed to determine the exact protective effect of vitamin D on BC risk.

Indexed as

AutophagyBreast NeoplasmsVitamin DApoptosisFemaleHumansVitamin D DeficiencyVitaminsVitamin DVitaminsBCbreast cancerGenomicsSystems biologyVitamin D

Identifiers

PMID39471001
PMCPMC11711349

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.