Evidence map›Paper›PMID 39470816›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

Ameliorative effects of osthole on acrylamide-induced neurotoxicity in PC12 cells: Role of oxidative stress, apoptosis and ERK pathways.

Leili Kachranlouei, Hossein Hosseinzadeh, Gholamreza Karimi, Fatemeh Rajabian, Soghra Mehri

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Effects of Acrylamide on Mouse Implantation and Decidualization.International journal of molecular sciences · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Leili KachranloueiSchool of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Hossein HosseinzadehPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, P. O. Box, Mashhad, 1365-91775, IR, Iran.
Gholamreza KarimiPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, P. O. Box, Mashhad, 1365-91775, IR, Iran.
Fatemeh RajabianDepartment of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Soghra MehriPharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, P. O. Box, Mashhad, 1365-91775, IR, Iran. MehriS@mums.ac.ir.

Funding

Mashhad University of Medical Sciences 981870
6 · The paper itself

Abstract

The possible protective effects of osthole on acrylamide-induced neurotoxicity in PC12 cells. Cells were pretreated with different concentrations of osthole (1- 25 μM) for 24 h and then the IC

Indexed as

AcrylamideApoptosisCoumarinsMAP Kinase Signaling SystemNeuroprotective AgentsOxidative StressAnimalsbcl-2-Associated X ProteinCaspase 3Cell SurvivalDNA FragmentationExtracellular Signal-Regulated MAP KinasesNeurotoxicity SyndromesPC12 CellsProto-Oncogene Proteins c-bcl-2RatsAcrylamidebcl-2-Associated X ProteinCaspase 3CoumarinsExtracellular Signal-Regulated MAP KinasesNeuroprotective AgentsostholProto-Oncogene Proteins c-bcl-2Reactive Oxygen SpeciesAcrylamideApoptosisNeurotoxicityOstholeOxidative stress

Identifiers

PMID39470816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.