ArticleNucleic acids research2024
Unveiling host-parasite relationships through conserved MITEs in prokaryote and viral genomes.
Article in Nucleic acids research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Jumbo circular extrachromosomal elements of methane-oxidizing archaea with variably extensive metabolic and defense gene repertoires.Nature communications · 2026Article
- Community and functional stability in a working bioreactor degrading 1,4-dioxane at the Lowry Landfill Superfund Site.Applied and environmental microbiology · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Transposable elements (TEs) play a pivotal role in the evolution of genomes across all life domains. 'Miniature Inverted-repeat Transposable-Elements' (MITEs) are non-autonomous TEs mainly located in intergenic regions, relying on external transposases for mobilization. The extent of MITEs' mobilome was explored across nearly 1700 prokaryotic genera, 183 232 genomes, revealing a broad distribution. MITEs were identified in 56.5% of genomes, totaling over 1.4 million cMITEs (cellular MITEs). Cluster analysis revealed that 97.4% of cMITEs were specific within genera boundaries, with up to 23% being species-specific. Subsequently, this genus-specificity was evaluated as a method to link microbial host to their viruses. A total of 51 655 cMITEs had counterparts in viral sequences, termed vMITEs (viral MITEs), resulting in the identification of 2500 viral sequences with them. Among these, 1501 sequences were positively assigned to a previously known host (41.8% were isolated viruses and 12.3% were assigned through CRISPR data), while 379 new host-virus associations were predicted. Deeper analysis in Neisseria and Bacteroidota groups allowed the association of 242 and 530 new viral sequences, respectively. MITEs are proposed as a novel approach to establishing valid virus-host relationships.
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Registered trials
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