Evidence map›Paper›PMID 39470579›Full record

ArticleJournal of cellular and molecular medicine2024

Exploring the prognostic value and potential therapeutic strategies of MS4A6A in glioblastoma: A comprehensive analysis of single-cell and multi-omics data.

Fangchao Wan, Yanling Li, Jianming Zhu, Dandan Yu, Hongjuan Liu, Bohong Hu

Abstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. The Myeloid BiomarkerInternational journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fangchao WanDepartment of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China.
Yanling LiDepartment of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China.
Jianming ZhuDepartment of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China.
Dandan YuDepartment of Electrocardiogram, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China.
Hongjuan LiuDepartment of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China.
Bohong HuDepartment of Neurology, Changde Hospital, Xiangya School of Medicine, Central South University, Changde, Hunan, China.ORCID 0009-0003-7088-5668

Funding

Hunan Provincial Health and Wellness Commission for Health Research W20243221
6 · The paper itself

Abstract

Glioblastoma (GBM) is a highly aggressive and treatment-resistant malignancy that poses a significant challenge in modern medicine. Despite advances in surgical resection, radiotherapy and chemotherapy, complete eradication of GBM remains elusive due to its diffuse invasion into the brain parenchyma and propensity for recurrence. The tumour microenvironment (TME), particularly macrophages, has emerged as a critical player in GBM progression, invasion and metastasis. In the immune microenvironment of glioma, MS4A6A exhibits unique expression characteristics in macrophages. This study aimed to investigate the potential role of MS4A6A, a gene associated with aging and neurodegenerative diseases, in GBM and its potential as a prognostic biomarker and therapeutic target.

Indexed as

Brain NeoplasmsGlioblastomaSingle-Cell AnalysisTumor MicroenvironmentBiomarkers, TumorGene Expression Regulation, NeoplasticHumansMacrophagesMultiomicsPrognosisBiomarkers, TumorgliomaMS4A6Amulti‐omicssingle cell

Identifiers

PMID39470579
PMCPMC11520442

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.