ArticleAmerican journal of respiratory cell and molecular biology2025
Volume-Regulated Anion Channel Complex Modulates Mechano-Electrical Signal Responses in Human Airway Smooth Muscle Shortening.
Joanna Woo, Gaoyuan Cao, Nikhil Karmacharya, Jordan Lee, Justin Lee, Kingsley C Duru, Conor McClenaghan, Steven S An, Reynold A Panettieri, Joseph A Jude
Article in American journal of respiratory cell and molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
10 authors.
Joanna WooJoint Graduate Program in Toxicology, Ernest Mario School of Pharmacy and.
Gaoyuan CaoRutgers Institute for Translational Medicine and Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey.
Nikhil KarmacharyaRutgers Institute for Translational Medicine and Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey.
Jordan LeeJoint Graduate Program in Toxicology, Ernest Mario School of Pharmacy and.
Justin LeeRutgers Institute for Translational Medicine and Science, Rutgers, The State University of New Jersey, New Brunswick, New Jersey.
Kingsley C DuruDepartment of Pharmacology, Rutgers Robert Wood Johnson Medical School, and.
Conor McClenaghanDepartment of Pharmacology, Rutgers Robert Wood Johnson Medical School, and.
Steven S AnJoint Graduate Program in Toxicology, Ernest Mario School of Pharmacy and.ORCID 0000-0003-4723-1888
Reynold A PanettieriJoint Graduate Program in Toxicology, Ernest Mario School of Pharmacy and.
Joseph A JudeJoint Graduate Program in Toxicology, Ernest Mario School of Pharmacy and.
Funding
Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
New Jersey Alliance for Clinical Translational Science: NJ ACTSUL1TR003017 · NCATS · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI PANETTIERI, REYNOLD ALEXANDER · 2019 to 2023
$28.9M
Project 4 - OGR1- and TSPO- dependent mechanisms mediated by benzodiazepines affecting ASM contractionP01HL114471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LIGGETT, STEPHEN B · 2013 to 2023
$23.9M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Targeting T2 inflammation-evoked mechanical endotypes of ASM shortening in asthmaR01HL164404 · NHLBI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Steven S An · 2023 to 2026
$2.2M
Summer Research Training in Environmental Health SciencesR25ES020721 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI Lauren M Aleksunes, Debra L Laskin · 2011 to 2026
$1.2M
NCATS NIH HHS UL1 TR003017NHLBI NIH HHS P01 HL114471NHLBI NIH HHS R01 HL164404NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R25 ES020721NIEHS NIH HHS T32 ES007148Office of Behavioral and Social Sciences Research P01HL114471Office of Behavioral and Social Sciences Research R01HL164404Office of Behavioral and Social Sciences Research T32ES007148Office of Behavioral and Social Sciences Research UL1TR003017
6 · The paper itself
Abstract
LRRC8A (leucine-rich repeat containing 8A) is an obligatory constituent of the volume-regulated anion channel (VRAC) that is fundamental to a wide range of biological processes, including regulating cell size, proliferation, and migration. Here we explored the physiological role of VRAC in excitation-contraction (E-C) coupling and shortening of human airway smooth muscle (HASM). In HASM cells, pharmacological inhibition of VRAC with DCPIB (4-[2-butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl]) (0.1-10 μM) markedly attenuated swell-activated Cl
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
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