ArticleAmerican journal of respiratory and critical care medicine2025
Airway Mucus Plugs on Chest Computed Tomography Are Associated with Exacerbations in Chronic Obstructive Pulmonary Disease.
Erratum issuedAbstract readMulticenter Study
In one paragraph
Article in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Oscillating Positive Expiratory Pressure (OPEP) Therapy in Bronchiectasis and Chronic Obstructive Pulmonary Disease (COPD): A Narrative Review of Clinical Studies.Pulmonary therapy · 2026Pooled it
- Artificial intelligence for mucus plug assessment: toward a new generation of airway imaging biomarkers.European radiology · 2026Article
- Radiologist and AI performance in detecting mucus plugs on chest CT.European radiology · 2026Article
- COPD Biologics: Right Patient, Right Pathway, Right Time.Pulmonary therapy · 2026Review
- Respiratory oscillometry in patients with chronic obstructive pulmonary disease with airway mucus plugs: insights from the ECLIPSE study.American journal of respiratory and critical care medicine · 2026Article
- Airway mucus plugs in asthma and chronic obstructive pulmonary disease: pathobiology, imaging, and implications for clinical trials.American journal of respiratory and critical care medicine · 2026Review
- Review
- Mucus Plugs and Eosinophilic Inflammation: Expanding the Paradigm to COPD.The journal of allergy and clinical immunology. In practice · 2026Review
- Airway mucus plugs in COPD clinical phenotypes and prognosis across stable and exacerbation states.Scientific reports · 2026Article
- A simple index for predicting mucus plugs in patients with chronic obstructive pulmonary disease.American journal of respiratory and critical care medicine · 2026Article
- Mucus plugs and exacerbations in tobacco-exposed people with normal and impaired spirometry.Annals of the American Thoracic Society · 2026Article
- When asthmatic distal airways lose their identity: a new mechanism of mucus plugs pathogenesis.American journal of respiratory and critical care medicine · 2026Article
- Mucus plugs-associated gene expression identifies pathophysiology shared with chronic bronchitis.American journal of respiratory and critical care medicine · 2026Article
- Molecular echoes of mucus plugging in chronic obstructive pulmonary disease.American journal of respiratory and critical care medicine · 2026Article
- Prediction of atelectasis inFrontiers in pediatrics · 2026Article
- Reply to Jie et al.: mucus plugs on chest CT as COPD risk factor: gaps in the evidence.American journal of respiratory and critical care medicine · 2026Article
- Narrative review: mucus plugging in chronic obstructive lung diseases and bronchiectasis.European clinical respiratory journal · 2026Review
- Lower lobe mucus plug distribution and future respiratory exacerbations in tobacco-exposed individuals with and without COPD.The European respiratory journal · 2026Article
- Beyond Blood Eosinophils: Target-Tier Heterogeneity and Patient Enrichment in COPD Type 2 Inflammation.Journal of inflammation research · 2026Review
- Research Hotspots and Future Trends of Oxygen Therapy for COPD: A Bibliometric and Visualization Analysis from 1973 to 2024.International journal of chronic obstructive pulmonary disease · 2026Article
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
25 authors.
Emily WanChanning Division of Network Medicine.ORCID 0000-0002-4126-2467
Andrew YenDepartment of Radiology, University of California, San Diego, San Diego, California.
Rim ElalamiDivision of Pulmonary and Critical Care Medicine.
Scott GrumleyDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Hrudaya P NathDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Wei WangDepartments of Medicine and Neurology, and.
Sharon BrouhaDepartment of Radiology, University of California, San Diego, San Diego, California.
Padma P ManapragadaDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Mostafa AbozeedDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Muhammad Usman AzizDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Mohd ZahidDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Asmaa N AhmedDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Nina L TerryDepartment of Radiology, University of Alabama at Birmingham, Birmingham, Alabama.
Pietro NardelliDepartment of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
James C RossDepartment of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.
Victor KimLewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania.
Sushilkumar SonavaneDepartment of Radiology, Mayo Clinic, Jacksonville, Florida.
Seth J KligermanDepartment of Radiology, National Jewish Health, Denver, Colorado.
Jørgen VestboDivision of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, United Kingdom.ORCID 0000-0001-6355-6362
Alvar AgustiRespiratory Institute, Hospital Clinic, Barcelona, Spain.ORCID 0000-0003-3271-3788
Kangjin KimChanning Division of Network Medicine.
Raúl San José EstéparDepartment of Radiology, Brigham and Women's Hospital, Boston, Massachusetts.ORCID 0000-0002-3677-1996
Edwin K SilvermanChanning Division of Network Medicine.
Michael H ChoChanning Division of Network Medicine.ORCID 0000-0002-4907-1657
Alejandro A DiazDivision of Pulmonary and Critical Care Medicine.ORCID 0000-0001-5037-2919
Funding
Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9MMetabolomic signatures of empysema and COPD progression in the COPDGene cohortR01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2012 to 2016
$31.1MGENETIC EPIDEMIOLOGY OF COPD (COPD GENE) TASK A: STUDY VISIT 4, COLLECTION OF COPDGENE STUDY DATA ANDBIOSPECIMENS AND OVERSIGHT OF THE COPDGENE STUDY75N92023D00011 · NHLBI · NATIONAL JEWISH HEALTH · PI NEWMAN, LEE S · 2023 to 2025
$29.6MRespiratory Computational Discovery CoreP01HL114501 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHOI, MARY E · 2013 to 2025
$24.9MGenetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M(2 of 2) Genetic Epidemiology of COPDR01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2012 to 2016
$18.9MCOPD Susceptibility, Heterogeneity, and Progression: Proteomics and GeneticsR01HL133135 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MORITZ, ROBERT L, SILVERMAN, EDWIN K · 2017 to 2025
$7.2MGenetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4qR01HL147148 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., SILVERMAN, EDWIN K · 2019 to 2022
$3.5MIdentifying Protein-Protein Network Interactions between COPD Susceptibility GenesR01HL152728 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K, WEI, WENYI · 2021 to 2024
$3.2MClinical Implications, Genomics, and Transcriptions of Mucus Plugging in SmokersR01HL149861 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI CHO, MICHAEL H., DIAZ, ALEJANDRO · 2020 to 2023
$3.2MUnderstanding airway mucus dysfunction in population-based studiesR01HL164824 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2022 to 2025
$2.7MClinical implications and Proteomics of Bronchiectasis Progression in SmokersR01HL173017 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Alejandro Diaz, Raul San Jose Estepar · 2024 to 2026
$2.6MCOPD FoundationCSRD VA I01 CX002193Manchester Biomedical Research CentreNHLBI NIH HHS 75N92023D00011NHLBI NIH HHS P01 HL114501NHLBI NIH HHS R01 HL089856NHLBI NIH HHS R01 HL089897NHLBI NIH HHS R01 HL133135NHLBI NIH HHS R01 HL147148NHLBI NIH HHS R01 HL149861NHLBI NIH HHS R01 HL152728NHLBI NIH HHS R01 HL164824NHLBI NIH HHS R01 HL173017NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897U.S. Department of Veterans Affairs CX 002193
Abstract
PubMed holds no abstract for this paper.
Indexed as
MucusPulmonary Disease, Chronic ObstructiveTomography, X-Ray ComputedAgedDisease ProgressionFemaleHumansMaleMiddle AgedProspective StudiesCOPDCOPD–diagnostic imagingCOPD exacerbationsmucus plugs
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.