Evidence map›Paper›PMID 39470247›Full record

ArticlemSystems2024

Antimicrobial and antibiofilm activity of human recombinant H1 histones against bacterial infections.

Betsy Verónica Arévalo-Jaimes, Mónica Salinas-Pena, Inmaculada Ponte, Albert Jordan, Alicia Roque, Eduard Torrents

Abstract read
In one paragraph

Article in mSystems, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Betsy Verónica Arévalo-JaimesBacterial infections and antimicrobial therapies group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0002-3363-5403
Mónica Salinas-PenaMolecular Biology Institute of Barcelona (IBMB-CSIC), Barcelona, Spain.
Inmaculada PonteBiochemistry and Molecular Biology Department, Universitat Autònoma de Barcelona, Bellaterra, Spain.ORCID 0000-0002-9448-6915
Albert JordanMolecular Biology Institute of Barcelona (IBMB-CSIC), Barcelona, Spain.ORCID 0000-0002-3970-8693
Alicia RoqueBiochemistry and Molecular Biology Department, Universitat Autònoma de Barcelona, Bellaterra, Spain.ORCID 0000-0002-6206-6481
Eduard TorrentsBacterial infections and antimicrobial therapies group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain.ORCID 0000-0002-3010-1609

Funding

Generalitat de Catalunya (Government of Catalonia) 2021SGR01545'la Caixa' Foundation ('la Caixa') LCF/BQ/DI20/11780040Ministerio de Ciencia e Innovación (MCIN) PID2020-112783GB-C21Ministerio de Ciencia e Innovación (MCIN) PID2020-112783GB-C22Ministerio de Ciencia e Innovación (MCIN) PID2021-125801OB-100, PLEC2022-009356, and PDC2022-133577-I00
6 · The paper itself

Abstract

Histones possess significant antimicrobial potential, yet their activity against biofilms remains underexplored. Moreover, concerns regarding adverse effects limit their clinical implementation. We investigated the antibacterial efficacy of human recombinant histone H1 subtypes against

Indexed as

Anti-Bacterial AgentsBiofilmsHistonesPseudomonas aeruginosaRecombinant ProteinsAnimalsCiprofloxacinGentamicinsHumansLarvaMicrobial Sensitivity TestsMothsPseudomonas InfectionsAnti-Bacterial AgentsCiprofloxacinGentamicinsHistonesRecombinant Proteinsantimicrobial peptidesbiofilmGalleria mellonellaproteinstoxicitytreatment

Identifiers

PMID39470247
PMCPMC11575268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.