Evidence map›Paper›PMID 39470204›Full record

ArticleAntimicrobial agents and chemotherapy2024

Identification and characterization of thiamine analogs with antiplasmodial activity.

Imam Fathoni, Terence C S Ho, Alex H Y Chan, Finian J Leeper, Kai Matuschewski, Kevin J Saliba

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Imam FathoniResearch School of Biology, The Australian National University, Canberra, Australia.
Terence C S Ho *Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Alex H Y Chan *Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Finian J LeeperYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, United Kingdom.
Kai MatuschewskiDepartment of Molecular Parasitology, Institute of Biology, Humboldt University Berlin, Berlin, Germany.
Kevin J SalibaResearch School of Biology, The Australian National University, Canberra, Australia.ORCID 0000-0003-3345-8440

Funding

Australian Government Research Training ProgramGerman Academic Research ExchangeK.M. Medhealth
6 · The paper itself

Abstract

Thiamine is metabolized into thiamine pyrophosphate (TPP), an essential enzyme cofactor. Previous work has shown that oxythiamine, a thiamine analog, is metabolized by thiamine pyrophosphokinase (TPK) into oxythiamine pyrophosphate within the malaria parasite

Indexed as

AntimalarialsPlasmodium falciparumThiamineAnimalsHumansMalariaMalaria, FalciparumMiceMolecular Docking SimulationOxythiaminePlasmodium bergheiThiamine PyrophosphateThiamin PyrophosphokinaseTransketolaseAntimalarialsOxythiamineThiamineThiamine PyrophosphateThiamin PyrophosphokinaseTransketolaseantiplasmodial agentsmalariaN3PTPlasmodium bergheiPlasmodium falciparumPlasmodium knowlesithiamine analogsvitamin B1

Identifiers

PMID39470204
PMCPMC11619390

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.