ArticleChemical communications (Cambridge, England)2024
Synthesis and Frizzled-receptor binding of a WNT5A hairpin-3 peptide.
Article in Chemical communications (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
We synthesized a WNT5A β-hairpin peptide responsible for the protein's binding to its receptor, Frizzled. Full affinity to Frizzled requires all three disulfides but not an invariant tryptophan that significantly contributes to the buried surface area. Our work opens the avenue to target the Wnt-Fzd interface using synthetic peptides.
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