Evidence map›Paper›PMID 39469595›Full record

ArticlePeerJ2024

Antimicrobial and anti-endotoxin activity of N-acetylcysteine, calcium hydroxide and their combination against

Rayana Duarte Khoury, Amjad Abu Hasna, Carolina Fedel Gagliardi, Renata Marques de Melo Marinho, Cláudio Antonio Talge Carvalho, Eduardo Bresciani, Marcia Carneiro Valera

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In one paragraph

Article in PeerJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. PeerJ · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rayana Duarte KhouryDepartment of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, Campus of São José dos Campos, São Paulo State University (ICT-Unesp), São José dos Campos, São Paulo, Brazil.
Amjad Abu HasnaDepartment of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, Campus of São José dos Campos, São Paulo State University (ICT-Unesp), São José dos Campos, São Paulo, Brazil.ORCID 0000-0002-1112-985X
Carolina Fedel GagliardiDepartment of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, Campus of São José dos Campos, São Paulo State University (ICT-Unesp), São José dos Campos, São Paulo, Brazil.
Renata Marques de Melo MarinhoDepartment of Dental Materials and Prosthodontics, Institute of Science and Technology, Campus of São José dos Campos, São Paulo State University (ICT-UNESP), São José dos Campos, São Paulo, Brazil.
Cláudio Antonio Talge CarvalhoDepartment of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, Campus of São José dos Campos, São Paulo State University (ICT-Unesp), São José dos Campos, São Paulo, Brazil.
Eduardo BrescianiDepartment of Restorative Dentistry, Institute of Science and Technology, Campus of São José dos Campos, São Paulo State University (ICT-Unesp), São José dos Campos, São Paulo, Brazil.ORCID 0000-0001-9299-8792
Marcia Carneiro ValeraDepartment of Restorative Dentistry, Endodontics Division, Institute of Science and Technology, Campus of São José dos Campos, São Paulo State University (ICT-Unesp), São José dos Campos, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The management of endodontic infections is a complex challenge, mainly due to the involvement of diverse microorganisms and their by-products. This study aimed to evaluate the efficacy of N-acetylcysteine (NAC), calcium hydroxide (Ca(OH) Methods: A total of 60 single-rooted human teeth were carefully selected and divided into six groups. These tooth canals were deliberately exposed to Results: The findings of this study showed significant reductions in the microbial load of

Indexed as

AcetylcysteineCalcium HydroxideEnterococcus faecalisEscherichia coliLipopolysaccharidesAnti-Bacterial AgentsAnti-Infective AgentsBiofilmsDental Pulp CavityHumansRoot Canal IrrigantsAcetylcysteineAnti-Bacterial AgentsAnti-Infective AgentsCalcium HydroxideLipopolysaccharidesRoot Canal IrrigantsCalcium hydroxideEnterococcus faecalisEscherichia coliLipopolysaccharidesN-acetylcysteine

Identifiers

PMID39469595
PMCPMC11514762

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.