ArticleIranian endodontic journal2024
Proteins Associated with Persistent Apical Periodontitis: A Scoping Review.
Article in Iranian endodontic journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of the prevalence of Behcet's disease in recurrent aphthous ulceration worldwide: a systematic review.Medicina oral, patologia oral y cirugia bucal · 2025Pooled it
- Genetic Analysis ofGenes · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This scoping review aimed to assess immunohistochemical markers associated with the physiopathogenesis of Persistent Apical Periodontitis. The protocol was adapted from the Joanna Briggs Institute Reviewer's Manual (2017) and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines for Scoping Reviews. A total of 239 articles were considered potentially eligible, and their full texts read by two reviewers. Six articles were included. The included articles were published between 1999 and 2017. A total of 12 biomarkers were identified, forkhead box P3, cluster of differentiation (CD)3, CD8, CD450, CD68, transforming growth factor alpha, transforming growth factor-beta1, matrix metalloproteinase-9, receptor activator of nuclear factor kappa beta ligand, osteoprotegerin, CD90 and sex-determining region Y-box 2; categorized according to their applicability. Among the biomarkers identified, receptor activator of nuclear factor kappa beta ligand and osteoprotegerinare were related to bone remodeling in apical periodontitis and may also be associated with persistent apical periodontitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.