Evidence map›Paper›PMID 39469452›Full record

ArticleFrontiers in cellular and infection microbiology2024

The influence of perilipin 5 deficiency on gut microbiome profiles in murine metabolic dysfunction-associated fatty liver disease (MAFLD) and MAFLD-hepatocellular carcinoma.

Marinela Krizanac, Paula Štancl, Paola Berenice Mass-Sanchez, Rosa Karlić, Diana Moeckel, Twan Lammers, Anastasia Asimakopoulos, Ralf Weiskirchen

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marinela Krizanac *Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.
Paula Štancl *Bioinformatics Group, Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.
Paola Berenice Mass-SanchezInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.
Rosa KarlićBioinformatics Group, Division of Molecular Biology, Department of Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia.
Diana MoeckelInstitute for Experimental Molecular Imaging, RWTH Aachen, Aachen, Germany.
Twan LammersInstitute for Experimental Molecular Imaging, RWTH Aachen, Aachen, Germany.
Anastasia AsimakopoulosInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.
Ralf WeiskirchenInstitute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Aachen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as the leading cause of hepatocellular carcinoma (HCC) worldwide. Over the years, Perilipin 5 (PLIN5) has been recognized as a key regulator of both MAFLD and HCC development. In our previous studies we demonstrated that deficiency in Methods: Therefore, we conducted a study to investigate the alterations in fecal microbiome composition in wild type (WT) and Results: Notably, we discovered that the absence of Discussion: Our findings identify

Indexed as

Carcinoma, HepatocellularDisease Models, AnimalFecesGastrointestinal MicrobiomeLiver NeoplasmsMice, KnockoutPerilipin-5AnimalsBacteriaFatty LiverMaleMiceMice, Inbred C57BLRNA, Ribosomal, 16SPerilipin-5RNA, Ribosomal, 16Sanimal modelsfatty liver diseasehepatocellular carcinomametabolic dysfunctionmetabolic syndromemicrobial diversitymicrobiome

Identifiers

PMID39469452
PMCPMC11513398

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.