In one paragraphArticle in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Diane D ParkDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School 110 Francis Street, Suite 9F, 330 Brookline Ave Boston MA 02215 USA echaikof@bidmc.harvard.edu +1-617-632-9581 +1-617-632-9701.ORCID https://orcid.org/0000-0003-4983-4340 Simon S ParkDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School 110 Francis Street, Suite 9F, 330 Brookline Ave Boston MA 02215 USA echaikof@bidmc.harvard.edu +1-617-632-9581 +1-617-632-9701.ORCID https://orcid.org/0000-0001-8948-7641 Erbin DaiDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School 110 Francis Street, Suite 9F, 330 Brookline Ave Boston MA 02215 USA echaikof@bidmc.harvard.edu +1-617-632-9581 +1-617-632-9701.
Carolyn A HallerDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School 110 Francis Street, Suite 9F, 330 Brookline Ave Boston MA 02215 USA echaikof@bidmc.harvard.edu +1-617-632-9581 +1-617-632-9701.
Daniel J WongDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School 110 Francis Street, Suite 9F, 330 Brookline Ave Boston MA 02215 USA echaikof@bidmc.harvard.edu +1-617-632-9581 +1-617-632-9701.
Walter J WeverDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School 110 Francis Street, Suite 9F, 330 Brookline Ave Boston MA 02215 USA echaikof@bidmc.harvard.edu +1-617-632-9581 +1-617-632-9701.ORCID https://orcid.org/0000-0002-5754-0652 Richard D CummingsDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School 110 Francis Street, Suite 9F, 330 Brookline Ave Boston MA 02215 USA echaikof@bidmc.harvard.edu +1-617-632-9581 +1-617-632-9701.
Elliot L ChaikofDepartment of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School 110 Francis Street, Suite 9F, 330 Brookline Ave Boston MA 02215 USA echaikof@bidmc.harvard.edu +1-617-632-9581 +1-617-632-9701.ORCID https://orcid.org/0000-0001-6184-4571 Funding
HARVARD-LONGWOOD RESEARCH TRAINING IN VASCULAR SURGERYT32HL007734 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI FERRAN, CHRISTIANE, LOGERFO, FRANK W · 1993 to 2023
$10.5MFacile Synthesis of Glycosulfopeptides and Related BioconjugatesU01GM116196 · NIGMS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHAIKOF, ELLIOT, CUMMINGS, RICHARD D · 2015 to 2018
$2.6MA PSGL-1 Glycopeptide Mimetic for Treatment of Metabolic SyndromeR01DK107405 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHAIKOF, ELLIOT, KAHN, BARBARA B. · 2016 to 2019
$2.5MA PSGL-1 Glycopeptide Mimetic for Treatment of Venous ThromboembolismR01HL128237 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CHAIKOF, ELLIOT · 2015 to 2018
$1.7MNHLBI NIH HHS R01 HL128237NHLBI NIH HHS T32 HL007734NIDDK NIH HHS R01 DK107405NIGMS NIH HHS U01 GM116196
6 · The paper itselfAbstract
Peptide-based therapeutics are recognized as potent and selective molecules but are often limited by short circulating half-lives, instability towards enzymatic degradation, and immunogenicity. To address these limitations and improve their pharmacological properties, peptides are commonly modified by the covalent attachment of polyethylene glycol (PEG). However, the large molecular weight and polydispersity of PEG chains complicate the interpretation of the full structure of PEGylated peptide therapeutics using standard analytical techniques. Here, we developed a mass spectrometric-based workflow in negative ion mode to identify and quantify GSnP-6, a P-selectin antagonist, with a linear 10 kDa PEG (PEG10) attached at the N-terminus of the glycopeptide. Intact mass analysis with multiple microscans allowed accurate measurements of precursor ions in complex biological mixtures with baseline resolution. Utilizing stepped collision energies improved sequence coverage and enabled identification of key amino acid modifications. We show the utility of this approach in evaluating the properties of PEG10-GSnP-6
Identifiers
PMID39469021
PMCPMC11513618
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