ArticleRSC advances2024
Ionic resorcinarenes as drug solubilization agents in water.
Article in RSC advances, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Effect of SodiumInternational journal of molecular sciences · 2026Article
- Reversing the Fold: Polyanionic Macrocycle Dissolves αA66-80 Crystallin Peptide Aggregates.Biomacromolecules · 2026Article
- Synthesis and X‑ray Structures of Bis-Functional Resorcinarene Crown Ethers.Crystal growth & design · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resorcinarenes are capable of host-guest complexation with small molecules, however, they are less studied as pharmaceutical drug delivery aids. This article reports on the aqueous-solubility enhancing effect of an octa-sulfonated resorcinarene and a C-hydroxybenzyl ammonium resorcinarene chloride on three hydrophobic drugs: isoniazid, caffeine, and griseofulvin. The findings are backed by dynamic light scattering, isothermal calorimetric titration, and nuclear magnetic resonance experiments in water. Aqueous mixtures of equal volumes of drug compounds and resorcinarene solutions produced a more soluble and clearer unit than solutions of pure drug compounds in water. Light scattering experiments revealed shifts in particle sizes of pure drug compounds to the range of resorcinarene hosts.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.