Evidence map›Paper›PMID 39468776›Full record

ArticleThe Journal of infectious diseases2025

High Mortality Rates Among Individuals Misdiagnosed With Tuberculosis: A Matched Retrospective Cohort Study of Individuals Diagnosed With Tuberculosis in Brazil.

Ryan R Thompson, Sun Kim, Daniele Maria Pelissari, Luiza Ohana Harada, José Nildo de Barros Silva, Patricia Bartholomay Oliveira, Marcia C Castro, Ted Cohen, Nicolas A Menzies

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ryan R ThompsonDepartment of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0001-6965-7770
Sun KimDepartment of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Daniele Maria PelissariHealth and Environment Surveillance Secretariat, Ministry of Health, Brasilia, Brazil.
Luiza Ohana HaradaHealth and Environment Surveillance Secretariat, Ministry of Health, Brasilia, Brazil.
José Nildo de Barros SilvaHealth and Environment Surveillance Secretariat, Ministry of Health, Brasilia, Brazil.
Patricia Bartholomay OliveiraHealth and Environment Surveillance Secretariat, Ministry of Health, Brasilia, Brazil.
Marcia C CastroDepartment of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.
Ted CohenDepartment of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut.
Nicolas A MenziesDepartment of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, Massachusetts.

Funding

Optimal targeting for individual and population-level TB preventionR01AI146555 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI MENZIES, NICOLAS A · 2020 to 2024
$2.5M
NIAID NIH HHS R01 AI146555US National Institutes of Health R01AI146555
6 · The paper itself

Abstract

We conducted a matched retrospective cohort study comparing mortality among individuals receiving a false-positive tuberculosis (TB) diagnosis (n = 3701) to individuals correctly diagnosed with TB (n = 8595) in Brazil from 2007 to 2016. Over an average 5.4-year follow-up period, we estimated a mortality rate ratio of 1.95 (95% confidence interval, 1.80-2.11) for individuals incorrectly diagnosed with TB compared to controls. The leading causes of death among the misdiagnosed were malignant neoplasms (40.9%) and respiratory system disorders (15.9%), conditions with symptoms similar to TB. Our findings highlight the need for improved follow-up care after identification of false-positive cases to increase survival for this high-risk population.

Indexed as

Diagnostic ErrorsTuberculosisAdolescentAdultAgedBrazilChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedRetrospective StudiesYoung AdultBrazilelectronic medical recordsmisdiagnosissurvival analysistuberculosis

Identifiers

PMID39468776
PMCPMC12128048

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.