ArticleJournal of experimental botany2025
Identification of genes associated with sex expression and sex determination in hemp (Cannabis sativa L.).
Article in Journal of experimental botany, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Genetic Advances inPlants (Basel, Switzerland) · 2026Review
- An X-linked sex determination mechanism in cannabis and hop.Nature communications · 2026Article
- Weeding out variability: a proof-of-concept for producing uniform FHorticulture research · 2026Article
- Network ontology transcript annotation identifies genetic signals underlying sex determination.Scientific reports · 2026Article
- Multiplex high resolution melting using MADC2 and SCAR markers for sex identification of Cannabis sativa L. cultivation.Scientific reports · 2026Article
- Transcriptomic insights into unisexual flower development in Cannabis sativa: conserved MADS-box networks and divergent developmental programs.BMC plant biology · 2026Article
- Research Progress on Flowering Period of Hemp.Plants (Basel, Switzerland) · 2026Review
- Sex-specific ethylene responses drive floral sexual plasticity in Cannabis sativa.The Plant journal : for cell and molecular biology · 2026Article
- Gibberellin pathway remodeling accompanies ethylene-driven sex reversal inFrontiers in plant science · 2026Article
- FT-like genes in Cannabis and hops: sex specific expression and copy-number variation may explain flowering time variation.BMC genomics · 2025Article
- A simple and reliable PCR-based method to differentiate between XX and XY sex genotypes in Cannabis sativa.Planta · 2025Article
- Characterization and transcriptomic analysis provide novel insights into the sexual differentiation of the dioecious plant Bama Huoma (Cannabis sativa).BMC plant biology · 2025Article
- An X-linked sex determination mechanism in cannabis and hop.bioRxiv : the preprint server for biology · 2025Article
- Improving medicinal plant cultivation through in-depth understanding of environmental, physiological, metabolic, and genetic constraints.Journal of experimental botany · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
Dioecy in flowering plants has evolved independently many times, and thus the genetic mechanisms underlying sex determination are diverse. In hemp (Cannabis sativa), sex is controlled by a pair of sex chromosomes (XX for females and XY for males). In an attempt to understand the molecular mechanism responsible for sex expression in hemp plants, we carried out RNA sequencing of male and female plants at different developmental stages. Using a pipeline involving differential gene expression analysis and weighted gene co-expression network analysis, we identified genes important for male and female flower development. We also demonstrate that sex-biased expression is already established at very early vegetative stages, before the onset of reproductive development, and identify several genes encoding transcription factors of the REM, bZIP, and MADS families as candidate sex-determination genes in hemp. Our findings demonstrate that the gene regulatory networks governing male and female development in hemp diverge at a very early stage, leading to profound morphological differences between male and female hemp plants.
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