Evidence map›Paper›PMID 39468535›Full record

ArticleBMC biology2024

Hoxa5 alleviates adipose tissue metabolic distortions in high-fat diet mice associated with a reduction in MERC.

Qi Chen, Zeyu Ren, Liping Dang, Zunhai Liu, Simeng Wang, Xinhao Chen, Guiping Qiu, Chao Sun

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Article in BMC biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qi ChenCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xi Nong Roud, Yangling, 712100, Shaanxi, China.
Zeyu RenCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xi Nong Roud, Yangling, 712100, Shaanxi, China.
Liping DangCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xi Nong Roud, Yangling, 712100, Shaanxi, China.
Zunhai LiuCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xi Nong Roud, Yangling, 712100, Shaanxi, China.
Simeng WangCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xi Nong Roud, Yangling, 712100, Shaanxi, China.
Xinhao ChenCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xi Nong Roud, Yangling, 712100, Shaanxi, China.
Guiping QiuCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xi Nong Roud, Yangling, 712100, Shaanxi, China.
Chao SunCollege of Animal Science and Technology, Northwest A&F University, No. 22 Xi Nong Roud, Yangling, 712100, Shaanxi, China. sunchao2775@163.com.ORCID 0000-0001-7222-4028

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMitochondria-endoplasmic reticulum membrane contact (MERC) is an important mode of intercellular organelle communication and plays a crucial role in adipose tissue metabolism. Functionality of Hoxa5 is an important transcription factor involved in adipose tissue fate determination and metabolic regulation, but the relationship between Hoxa5 and MERC is not well understood.

resultsIn our study, we established an obesity model mouse by high-fat diet (HFD), induced the alteration of Hoxa5 expression by adenoviral transfection, and explored the effect of Hoxa5 on MERC dysfunction and metabolic distortions of adipose tissue with the help of transmission electron microscopy, calcium ion probe staining, and other detection means. The results showed Hoxa5 was able to reduce MERC production, alleviate endoplasmic reticulum stress (ERS) and calcium over-transport, and affect cGAS-STING-mediated innate immune response affecting adipose tissue energy metabolism, as well as affect the AKT-IP3R pathway to alleviate insulin resistance and ameliorate metabolic distortions in adipose tissue of mice.

conclusionsOur results suggest that Hoxa5 can ameliorate high-fat diet-induced MERC overproduction and related functional abnormalities, in which finding is expected to provide new ideas for the improvement of obesity-related metabolic distortions.

Indexed as

Adipose TissueDiet, High-FatHomeodomain ProteinsAnimalsEndoplasmic ReticulumMaleMiceMice, Inbred C57BLMitochondriaObesityTranscription FactorsHomeodomain ProteinsHoxa5 protein, mouseTranscription FactorsCalcium ion homeostasisHoxa5Mitochondria-endoplasmic reticulum membrane contact (MERC)

Identifiers

PMID39468535
PMCPMC11520472

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.