Evidence map›Paper›PMID 39468238›Full record

ArticleScientific reports2024

Transcriptome reanalysis and gene expression of 13 detoxification genes for avermectin and pyridaben resistance in Panonychus citri.

Xiaoqing Han, Mengyuan Peng, Yunlong Zhang, Pan Wu, Xiaoyu Zheng, Xinze Zhang, Shuchen Guo, Yanhong Ding, Na Yang, Meng Li and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiaoqing Han *Central Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Mengyuan Peng *Central Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Yunlong ZhangCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Pan WuThe Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, China.
Xiaoyu ZhengThe Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Nankai University, Tianjin, China.
Xinze ZhangCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Shuchen GuoCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Yanhong DingCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Na YangCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Meng LiCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Yidong LvCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Yi ZhangCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Shuzhen LiuCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Guohua YuCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China.
Bin LiuCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China. liubinnk@nankai.edu.cn.
Liujun TianCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China. tianliujunttk@163.com.
Chongbin SunCentral Laboratory of the First Affiliated Hospital, WeiFang People's Hospital, Shandong Second Medical University, Weifang, 261000, China. LHuies@163.com.

Funding

National Natural Science Foundation of China 32100418
6 · The paper itself

Abstract

Citrus red mites (P. citri) are key pests affecting citrus production worldwide due to pesticide resistance. The resistance mechanisms of ten pesticides are known, but a comprehensive study using transcriptome data is missing. This study employed deeptools, cuffdiff, rmats, bcftools and other software to examine gene expression variation, alternative splicing (AS), and mutations in mite resistance. The research highlighted that pesticides can regulate gene transcription, and red mites with resistance increase cytochrome P450, glutathione S-transferases, carboxylesterase, and acetylcholinesterase expression. Pyridaben also induces new AS events. Fluazinam-induced mites show mRNA splicing peaking earlier than transcription, both peaking at one day and returning to baseline after two days. AS profiles are similar in different mite populations with overlapping pesticide resistances. Lastly, specific mitochondrial SNPs in mites might mediate resistance against select pesticides.

Indexed as

IvermectinMitesPyridazinesTranscriptomeAcaricidesAlternative SplicingAnimalsCitrusDrug ResistanceGene Expression ProfilingInactivation, MetabolicPolymorphism, Single NucleotideAcaricidesavermectinIvermectinpyridabenPyridazines

Identifiers

PMID39468238
PMCPMC11519329

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.