ArticleNature communications2024
Epigenetic memory of radiotherapy in dermal fibroblasts impairs wound repair capacity in cancer survivors.
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Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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25citing papers in PubMed, 2 pooled it
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Vascular Reconstruction in Extremity Soft Tissue Sarcomas: A Systematic Review and Single-Arm Meta-Analysis.Journal of surgical oncology · 2026Pooled it
- Progress in epigenetic research of breast cancer: a bibliometric analysis since the 2000s.Frontiers in oncology · 2025Pooled it
- Biomaterial-based extracellular vesicle delivery systems for wound healing: From fabrication to applications.Bioactive materials · 2026Review
- Mechanical regulation of cell memory.Nature structural & molecular biology · 2026Review
- Chronic Radiation-Induced Wounds: Pathogenesis, Current Therapeutic Strategies, and Emerging Regenerative Approaches.International journal of molecular sciences · 2026Review
- Lysyl oxidase (LOX) family proteins in extracellular matrix homeostasis: roles in disease and radiation-induced pathogenesis.Molecular biology reports · 2026Review
- AAVrh32.33 capsid demonstrates unexpected dermal tropism regardless of immunodominant epitope.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Fibroblasts as regulators of lung immunity, repair and fibrosis.Nature reviews. Immunology · 2026Review
- Soft Tissue Scaffolds in Breast Reconstruction: Evolution from Acellular Dermal Matrices to Synthetic Polymers.Journal of clinical medicine · 2026Review
- Cardiac radiotherapy-induced epigenetic memory underlies electrophysiologic and metabolic reprogramming.The Journal of clinical investigation · 2026Article
- Distinctive DNA sequence features define epigenetic longevity of inflammatory memory.Science (New York, N.Y.) · 2026Article
- Impact of neoadjuvant chemotherapy on the functionality of adipose-derived mesenchymal stromal cells and their modulatory effects on fibroblasts in oncology patients.Scientific reports · 2026Article
- Epigenetics: the master switch of nasopharyngeal carcinoma invasion and metastasis.Frontiers in immunology · 2026Review
- The therapy-conditioned host: a state-transition framework for second primary cancer evolution.Frontiers in oncology · 2026Article
- Attenuated crosstalk between urothelium and fibroblasts promotes ureteral stricture development.Frontiers in immunology · 2026Article
- The role of thrombospondin-1 in dermatological conditions.Frontiers in medicine · 2026Review
- Understanding and Advancing Wound Healing in the Era of Multi-Omic Technology.Bioengineering (Basel, Switzerland) · 2025Review
- In vitro repositioning therapy with olaparib, temozolomide and oxaliplatin in glioblastoma cell lines: U118, U87, U251, H4 and human fibroblasts.Pharmacological reports : PR · 2025Article
- Review
- Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance.Signal transduction and targeted therapy · 2025Review
Corrections and comments
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Authors and funding
20 authors.
Xiaowei Bian *Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0001-8999-7078
Minna Piipponen *Dermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Zhuang LiuDermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Lihua LuoDermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-2129-4226
Jennifer GearaDermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Yongjian ChenDermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Traimate SangsuwanDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Monica MaselliDermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden.
Candice DiazCentre de recherche en organogénèse expérimentale de l'Université Laval / LOEX, Québec, QC, Canada.
Connor A BainInstitute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK.
Evelien EenjesDepartment of Cell and Molecular Biology, Karolinska Institutet, Solna, Sweden.
Maria GenanderDepartment of Cell and Molecular Biology, Karolinska Institutet, Solna, Sweden.ORCID 0000-0002-2428-8040
Michael CrichtonInstitute of Mechanical, Process and Energy Engineering, School of Engineering and Physical Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK.
Jenna L CashCentre for Inflammation Research, Institute for Regeneration and Repair, 4-5 Little France Drive, University of Edinburgh, Edinburgh, EH16 4UU, UK.
Louis ArchambaultDepartment of Physics, Université Laval/Centre de Recherche sur le Cancer, Université Laval/Centre de recherche du CHU de Québec, Québec, QC, Canada.
Siamak HaghdoostDepartment of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Julie FradetteCentre de recherche en organogénèse expérimentale de l'Université Laval / LOEX, Québec, QC, Canada.
Pehr SommarDepartment of Plastic and Reconstructive Surgery, Karolinska University Hospital, Stockholm, Sweden.
Martin HalleDepartment of Plastic and Reconstructive Surgery, Karolinska University Hospital, Stockholm, Sweden. martin.halle@regionstockholm.se.ORCID 0000-0002-6222-956X
Ning Xu LandénDermatology and Venereology Division, Department of Medicine Solna, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. ning.xu@ki.se.ORCID 0000-0003-4868-3798
Funding
Gouvernement du Canada | Instituts de Recherche en Santé du Canada | Institute of Musculoskeletal Health and Arthritis (Institut de l'Appareil Locomoteur et de l'Arthrite) No. 384224/151708Radiumhemmets Forskningsfonder (Cancer Research Foundations of Radiumhemmet) No. 161072Stockholms Läns Landsting (Stockholm County Council) No. FoUI-962332Strålsäkerhetsmyndigheten (Radiation Safety Authority) Grant No. SSM2014-4016Svenska Läkaresällskapet (Swedish Society of Medicine) No. SLS-886621
Abstract
Radiotherapy (RT), a common cancer treatment, unintentionally harms surrounding tissues, including the skin, and hinders wound healing years after treatment. This study aims to understand the mechanisms behind these late-onset adverse effects. We compare skin biopsies from previously irradiated (RT
Indexed as
Breast NeoplasmsCancer SurvivorsEpigenesis, GeneticFibroblastsSkinWound HealingAnimalsEpigenetic MemoryFemaleHumansMiceMiddle AgedRadiotherapy
Identifiers
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.