ArticleNature communications2024
Integrative 3D genomics with multi-omics analysis and functional validation of genetic regulatory mechanisms of abdominal fat deposition in chickens.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed.
- Integrated Bulk and Single-Nucleus Transcriptomics Characterizes the Developmental and Regional Specialization of Chicken Abdominal Fat-Associated Tissue.Animals : an open access journal from MDPI · 2026Article
- Revealing the Shared Genetic Basis of Thermal Adaptation and Abdominal Adiposity in Wenchang Chicken Using Whole-Genome Structural Variation Analysis.Animals : an open access journal from MDPI · 2026Article
- Integrating single-nucleus RNA sequencing and gene perturbation reveals regulatory networks of intramuscular fat deposition in bovine skeletal muscle.Animal bioscience · 2026Article
- Integrated multi-omics analysis reveals molecular regulation of the hypothalamus-pituitary-ovary axis underlying egg production in indigenous chickens.Poultry science · 2026Article
- Multi-omics analysis identifies key microbial taxa and host genes controlling abdominal fat deposition in chickens.Poultry science · 2026Article
- Double-negative feedback loop between IGF2BP2 and miR-196-5p inhibits the proliferation and differentiation of primary chicken myoblasts.Poultry science · 2026Article
- Role ofZoological research · 2026Article
- Mining of important genetic loci and evaluation of genetic effects for growth traits in Baicheng You Chicken.Poultry science · 2026Article
- Multi-Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pan-3D Genome Analysis Reveals the Roles of Structural Variation in Chicken Chromatin Architectures, Domestication and Production Traits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Transcriptomic analysis identifies hub genes involved in age-dependent abdominal fat development in chickens.Poultry science · 2026Article
- Emerging technologies in poultry genomics: Unlocking innovation for the future of sustainable production.Poultry science · 2026Review
- An Integrative Genetic Strategy for Identifying Causal Genes at Quantitative Trait Loci in Chickens.Animals : an open access journal from MDPI · 2026Review
- Multi-omics dissection of the genetic regulation underlying fatty acid composition in cattle.Genome biology · 2025Article
- Identification and characterization of GHR gene promoter of yak.Scientific reports · 2025Article
- Genome-Wide Association Study of Abdominal and Intramuscular Fat Deposition Traits in Huainan Yellow-Feathered Chickens.Animals : an open access journal from MDPI · 2025Article
- Integrative multi-omics analysis reveals key regulatory nodes of abdominal fat deposition in broiler chickens.Poultry science · 2025Article
- Functional analysis of lncRNAs in lipid metabolism of fat and lean line broiler embryonic livers.Poultry science · 2025Article
- - Invited Review - Challenges and constraints to the sustainability of poultry farming in China.Animal bioscience · 2025Article
- From GWAS signal to function: targeted CRISPR activation enables functional characterization of non-coding SNPs in chickens.Frontiers in genome editing · 2025Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
Chickens are the most abundant agricultural animals globally, with controlling abdominal fat deposition being a key objective in poultry breeding. While GWAS can identify genetic variants associated with abdominal fat deposition, the precise roles and mechanisms of these variants remain largely unclear. Here, we use male chickens from two lines divergently selected for abdominal fat deposition as experimental models. Through the integration of genomic, epigenomic, 3D genomic, and transcriptomic data, we build a comprehensive chromatin 3D regulatory network map to identify the genetic regulatory mechanisms that influence abdominal fat deposition in chickens. Notably, we find that the rs734209466 variant functions as an allele-specific enhancer, remotely enhancing the transcription of IGFBP2 and IGFBP5 by the binding transcription factor IRF4. This interaction influences the differentiation and proliferation of preadipocytes, which ultimately affects phenotype. This work presents a detailed genetic regulatory map for chicken abdominal fat deposition, offering molecular targets for selective breeding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.