Evidence map›Paper›PMID 39467984›Full record

ArticleMolecular neurobiology2025

Complement Receptor 1 Is a Potential Extracerebral Factor Promoting α-Synuclein Pathology.

Yunying Yang, Sichun Chen, Yan Gao, Liqin Huang, Zehua Liu, Chaoyang Liu, Xin Fang, Zhentao Zhang

Abstract read
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In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yunying Yang *Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Sichun Chen *Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Yan GaoDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Liqin HuangDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Zehua LiuResearch Center for Environment and Health, Zhongnan University of Economics and Law, Wuhan, 430073, China.
Chaoyang LiuDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China.
Xin FangDepartment of Neurology, the First Affiliated Hospital of Nanchang University, Nanchang, 330000, China. fangx2011@163.com.
Zhentao ZhangDepartment of Neurology, Renmin Hospital of Wuhan University, Wuhan, 430060, China. zhentaozhang@whu.edu.cn.

Funding

the Innovative Research Groups of Hubei Province 2022CFA026the National Key Research and Development Program of China 2019YFE0115900the New 20 Terms of Universities in Jinan 202228022the Project for Academic and Technical Leaders of Major Disciplines in Jiangxi Province 20213BCJL22049
6 · The paper itself

Abstract

The deposition of pathological α-synuclein (α-Syn) in the central nervous system (CNS) is a hallmark of Parkinson's disease (PD). Notably, pathological α-Syn exists not only in the CNS but also in peripheral organs and body fluids in PD patients. Emerging evidence has shown the transmission of α-Syn pathology from the body to the brain. Nevertheless, the factors that drive the aggregation of peripheral α-Syn remain largely unknown. Here, we revealed that complement receptor 1 (CR1), a component of the peripheral blood system, acts as a promoter of α-Syn pathology. The transmembrane domain of CR1 (CR1-TM) exacerbates α-Syn phosphorylation and aggregation in vitro. Furthermore, intravenous injection of α-Syn fibrils induced the formation of α-Syn pathology in the brain. Co-administration of CR1-TM exacerbated α-Syn pathology induced by intravenous injection of preformed α-Syn fibrils. Our findings suggest that extracerebral factors such as CR1 can drive α-Syn pathology and serve as therapeutic targets for treating synucleinopathies.

Indexed as

alpha-SynucleinReceptors, Complement 3bAnimalsBrainHumansMaleMiceMice, Inbred C57BLParkinson DiseasePhosphorylationProtein Aggregation, Pathologicalalpha-SynucleinReceptors, Complement 3bAggregationComplement receptor 1PhosphorylationSeedingα-Synuclein

Identifiers

PMID39467984

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.