Evidence map›Paper›PMID 39467962›Full record

ArticleJournal of chemical ecology2024

Potent Nitrogen-containing Milkweed Toxins are Differentially Regulated by Soil Nitrogen and Herbivore-induced Defense.

Anurag A Agrawal, Amy P Hastings, Christophe Duplais

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of chemical ecology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anurag A AgrawalDepartment of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, 14853, USA. agrawal@cornell.edu.
Amy P HastingsDepartment of Ecology and Evolutionary Biology, Cornell University, Ithaca, NY, 14853, USA.
Christophe DuplaisDepartment of Entomology, Cornell AgriTech, Cornell University, Geneva, NY, 14456, USA.

Funding

Directorate for Biological Sciences IOS-2209762
6 · The paper itself

Abstract

Theories have been widely proposed and tested for impacts of soil nitrogen (N) on phytochemical defenses. Among the hundreds of distinct cardenolide toxins produced by milkweeds (Asclepias spp.), few contain N, yet these appear to be the most toxic against specialist herbivores. Because N- and non-N-cardenolides coexist in milkweed leaves and likely have distinct biosynthesis, they present an opportunity to address hypotheses about drivers of toxin expression. We tested effects of soil N and herbivore-damage on cardenolide profiles of two milkweed species differing in life-history strategies (Asclepias syriaca and A. curassavica), and the toxicity of their leaves. In particular leaf extracts were tested against the target enzymes (Na

Indexed as

AsclepiasButterfliesCardenolidesHerbivoryNitrogenPlant LeavesSoilAnimalsSodium-Potassium-Exchanging ATPaseToxins, BiologicalCardenolidesNitrogenSodium-Potassium-Exchanging ATPaseSoilToxins, BiologicalCardenolideCardiac glycosideChemical ecologyCoevolutionMonarch butterflyNa+/K+-ATPasePhytochemical diversitySodium–potassium pump

Identifiers

PMID39467962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.