Evidence map›Paper›PMID 39467892›Full record

Trial reportClinical oral investigations2024

Effectiveness of platelet-rich fibrin in third molar extractions: a randomized controlled split-mouth study.

Katharina Zwittnig, Barbara Kirnbauer, Astrid Truschnegg, Norbert Jakse, Axel Wolf, Alwin Sokolowski, Irene Mischak, Michael Payer

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical oral investigations, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05089812 nacompletednot on this map

The Effect of Platelet-rich Fibrin on Clinical and Patient-centered Outcomes of Third Molar Extractions

TypeinterventionalSponsorMedical University of GrazRan2021 to 2024Enrolled25ConditionsOral SurgeryArmsThird-molar extraction using platelet-rich fibrin as a filling of the alveolus
NCT07530068 nacompletednot on this mapstarted 2025, after this paper: background citation

Adjacent Molar Outcomes After Impacted Mandibular Third Molar Surgery With PRF or Collagen Sponge: A Randomized Split-Mouth Trial

TypeinterventionalSponsorGazi UniversityRan2025 to 2026Enrolled29ConditionsImpacted Mandibular Third Molar, Wound Healing, Postoperative PainArmsPlatelet-rich fibrin (PRF), Absorbable Collagen Sponge
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Katharina ZwittnigDivision of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.
Barbara KirnbauerDivision of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.
Astrid TruschneggDivision of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.
Norbert JakseDivision of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.
Axel WolfDepartment of Otorhinolaryngology, Medical University of Graz, Graz, Austria.
Alwin SokolowskiDivision of Restorative Dentistry, Periodontology and Prosthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.
Irene MischakDivision of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria.
Michael PayerDivision of Oral Surgery and Orthodontics, Department of Dental Medicine and Oral Health, Medical University of Graz, Graz, Austria. mi.payer@medunigraz.at.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo date, studies have only investigated the use of platelet-rich fibrin (PRF) after removal of third molars from the mandible or maxilla. Removal of the upper and lower third molars is typically combined into one session per side; therefore, this study aimed to investigate influence on PRF. MATERIALS AND

methodsThis prospective, single-blinded, randomized controlled, clinical trial (split-mouth design) included 25 patients. After third molar removal, the test group's sockets were treated with solid PRF clots, whereas the control group's sockets were conventionally treated. The primary outcome was swelling, which was measured digitally and analogously. Secondary outcomes included trismus, pus, hematoma, and clinical attachment loss (CAL) of the second molars on days 1, 3, 7, and 14. Patient-centered outcome measures and the consumption of painkillers and antibiotics were recorded on days 0-7. The t-test for paired samples, Wilcoxon test, and Chi-Square test were used for statistical analyses.

resultsSwelling was significantly lower on day 14 in the test group (p < 0.05). No statistically significant differences were observed in pain, trismus, and CAL. In the test group, the number of painkillers taken and the number of days of intake were significantly lower (p < 0.05).

conclusionsPRF caused a reduction of painkiller consumption and in the days painkillers were needed. PRF significantly considerably reduced swelling after 14 days. Owing to the lack of differences in other parameters, the integration of PRF application into routine wisdom tooth removal is critical. CLINICAL RELEVANCE: PRF affects the long-term outcomes of third molar removal by reducing swelling and reducing as well as shortening painkiller consumption.

trial registrationclinicaltrials.gov (NCT05089812).

Indexed as

Molar, ThirdPlatelet-Rich FibrinTooth ExtractionAdultFemaleHumansMalePostoperative ComplicationsProspective StudiesSingle-Blind MethodTooth, ImpactedTreatment OutcomeOral surgeryPlatelet-rich-fibrinRegenerative therapyThird molar surgery

Identifiers

PMID39467892
PMCPMC11519305

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.