Evidence map›Paper›PMID 39467683›Full record

ArticleZhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics2024

[Effects of propranolol on the biological behavior of human umbilical vein endothelial cells and the expression of SOX18, MMP-7, and VEGFA].

Pei Zhou, Si-Qing Xie, Li-Li Zhong, Xiao-Fang Ding

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
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Article in Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

4 authors.

Pei ZhouHunan Provincial Key Laboratory of Pediatric Respiratory Medicine, Children's Medical Center, Hunan Provincial People's Hospital/First Affiliated Hospital of Hunan Normal University, Changsha 410005, China.
Si-Qing XieHunan Provincial Key Laboratory of Pediatric Respiratory Medicine, Children's Medical Center, Hunan Provincial People's Hospital/First Affiliated Hospital of Hunan Normal University, Changsha 410005, China.
Li-Li ZhongHunan Provincial Key Laboratory of Pediatric Respiratory Medicine, Children's Medical Center, Hunan Provincial People's Hospital/First Affiliated Hospital of Hunan Normal University, Changsha 410005, China.
Xiao-Fang DingHunan Provincial Key Laboratory of Pediatric Respiratory Medicine, Children's Medical Center, Hunan Provincial People's Hospital/First Affiliated Hospital of Hunan Normal University, Changsha 410005, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effects of propranolol on the proliferation, apoptosis, migration, and tube formation ability of human umbilical vein endothelial cells (HUVEC), as well as its impact on the expression of sex-determining region Y-box 18 (SOX18), matrix metalloproteinase-7 (MMP-7), and vascular endothelial growth factor A (VEGFA).

methodsHUVEC were treated with different concentrations of propranolol, and cell viability was assessed using the CCK-8 method to determine the optimal concentration and treatment duration. The experiment consisted of a control group and groups treated with different concentrations of propranolol (50, 100, 150 μmol/L). Apoptosis, migration, and tube formation of HUVEC were observed using flow cytometry, wound healing assays, and tube formation assays. Western blot and real-time quantitative PCR were used to detect the expression levels of SOX18, MMP-7, and VEGFA proteins and mRNA.

resultsCompared to the control group, the apoptosis rate in the propranolol treatment groups increased significantly (

conclusionsPropranolol can inhibit the proliferation, migration, and tube formation ability of HUVEC and promote cell apoptosis, resulting in decreased expression levels of SOX18, MMP-7, and VEGFA.

Indexed as

ApoptosisHuman Umbilical Vein Endothelial CellsMatrix Metalloproteinase 7PropranololSOXF Transcription FactorsVascular Endothelial Growth Factor ACell MovementCell ProliferationHumansMatrix Metalloproteinase 7MMP7 protein, humanPropranololSOX18 protein, humanSOXF Transcription FactorsVascular Endothelial Growth Factor AVEGFA protein, humanHuman umbilical vein endothelial cellInfantile hemangiomaMatrix metalloproteinase-7PropranololSex-determining region Y-box 18Vascular endothelial growth factor A

Identifiers

PMID39467683
PMCPMC11527407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.