Evidence map›Paper›PMID 39467622›Full record

ArticleBritish journal of sports medicine2025

Device-measured vigorous intermittent lifestyle physical activity (VILPA) and major adverse cardiovascular events: evidence of sex differences.

Emmanuel Stamatakis, Matthew Ahmadi, Raaj Kishore Biswas, Borja Del Pozo Cruz, Cecilie Thøgersen-Ntoumani, Marie H Murphy, Angelo Sabag, Scott Lear, Clara Chow, Jason M R Gill and 1 more

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Article in British journal of sports medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Emmanuel StamatakisMackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia emmanuel.stamatakis@sydney.edu.au.ORCID http://orcid.org/0000-0001-7323-3225
Matthew AhmadiMackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.ORCID http://orcid.org/0000-0002-3115-338X
Raaj Kishore BiswasMackenzie Wearables Research Hub, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.
Borja Del Pozo CruzFaculty of Sports Sciences, Universidad Europea de Madrid, Madrid, Spain.ORCID http://orcid.org/0000-0003-3944-2212
Cecilie Thøgersen-NtoumaniDanish Centre for Motivation and Behaviour Science, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Syddanmark, Denmark.ORCID http://orcid.org/0000-0003-0255-1263
Marie H MurphyPhysical Activity for Health Research Centre, Moray House School of Education and Sport, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-3482-3323
Angelo SabagSchool of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
Scott LearFaculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-7614-755X
Clara ChowWestmead Applied Research Centre, University of Sydney and Department of Cardiology, Westmead Hospital, Sydney, New South Wales, Australia.
Jason M R GillSchool of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.ORCID http://orcid.org/0000-0003-3615-0986
Mark HamerInstitute of Sport Exercise and Health, Division Surgery Interventional Science, University College London, London, London, UK.ORCID http://orcid.org/0000-0002-8726-7992

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVigorous intermittent lifestyle physical activity (VILPA) refers to brief bouts of intense physical activity embedded into daily life.

objectiveTo examine sex differences in the dose-response association of VILPA with major adverse cardiovascular events (MACE) and its subtypes.

methodsUsing multivariable-adjusted cubic splines, we examined the associations of daily VILPA duration with overall MACE and its subtypes (incident myocardial infarction, heart failure and stroke) among non-exercisers (individuals self-reporting no leisure-time exercise and no more than one recreational walk per week) in the UK Biobank. We also undertook analogous analyses for vigorous physical activity among exercisers (individuals self-reporting participation in leisure-time exercise and/or recreational walking more than once a week).

resultsAmong 13 018 women and 9350 men, there were 331 and 488 all MACE, respectively, over a 7.9-year follow-up. In women, daily VILPA duration exhibited a near-linear dose-response association with all MACE, myocardial infarction and heart failure. In men, dose-reponse curves were less clear with less evidence of statistical signifigance. Compared with women with no VILPA, women's median daily VILPA duration of 3.4 min was associated with hazard ratios (HRs; 95% confidence intervals) of 0.55 (0.41 to 0.75) for all MACE and 0.33 (0.18 to 0.59) for heart failure. Women's minimum doses of 1.2-1.6 min of VILPA per day were associated with HRs of 0.70 (0.58 to 0.86) for all MACE, 0.67 (0.50 to 0.91) for myocardial infarction, and 0.60 (0.45 to 0.81) for heart failure. The equivalent analyses in UK Biobank's accelerometry sub-study exercisers suggested no appreciable sex differences in dose-response.

conclusionsAmong non-exercising women, small amounts of VILPA were associated with a substantially lower risk of all MACE, myocardial infarction and heart failure. VILPA may be a promising physical activity target for cardiovascular disease prevention, particularly in women unable or not willing to engage in formal exercise.

Indexed as

Cardiovascular DiseasesExerciseLife StyleAdultAgedFemaleHeart FailureHumansMaleMiddle AgedMyocardial InfarctionSex FactorsStrokeUnited KingdomCardiovascular DiseasesCohort StudiesExerciseHeart diseasePhysical activity

Identifiers

PMID39467622
PMCPMC11874358

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.