Evidence map›Paper›PMID 39467611›Full record

ArticleThe European respiratory journal2025

Body mass index trajectories from birth to early adulthood and lung function development.

Gang Wang, Jenny Hallberg, Simon Kebede Merid, Ashish Kumar, Susanna Klevebro, Baninia Habchi, Romanas Chaleckis, Craig E Wheelock, Natalia Hernandez-Pacheco, Sandra Ekström and 4 more

Abstract read
In one paragraph

Article in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Postnatal growth and childhood asthma in preterm and full-term twins: A cohort study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026
    Article
  2. Prevalence of Overweight and Obesity and Their Impact on Lung Function in Healthy Bulgarian Children and Adolescents: A Cross-Sectional Study.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Article
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  12. No Longer a Great Gulf Fixed? Introduction to anAmerican journal of respiratory and critical care medicine · 2025
    Article
  13. Review
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  15. Towards early detection and disease interception of COPD across the lifespan.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Gang WangDivision of Internal Medicine, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Sichuan, China gang.wang@ki.se.
Jenny HallbergDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Simon Kebede MeridDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Ashish KumarDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Susanna KlevebroDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Baninia HabchiUnit of Integrative Metabolomics, Institute of Environmental Medicine Karolinska Institute, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-9705-167X
Romanas ChaleckisUnit of Integrative Metabolomics, Institute of Environmental Medicine Karolinska Institute, Stockholm, Sweden.
Craig E WheelockUnit of Integrative Metabolomics, Institute of Environmental Medicine Karolinska Institute, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-8113-0653
Natalia Hernandez-PachecoDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Sandra EkströmDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Christer JansonDepartment of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.ORCID https://orcid.org/0000-0001-5093-6980
Inger KullDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Anna BergströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Erik MelénDepartment of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-8248-0663

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFew studies have investigated the influence of body mass index (BMI) trajectories on lung function covering the entire growth period.

methodsWe conducted a prospective study using data from the Swedish BAMSE birth cohort. Latent class mixture modelling was employed to examine the diversity in BMI z-scores from birth to 24 years of age. Participants with four or more BMI z-scores were included (n=3204, 78.4%). Pre-bronchodilator spirometry was tested at 8, 16 and 24 years, while post-bronchodilator spirometry, multiple-breath nitrogen washout (for lung clearance index) and urinary metabolomics data were assessed at 24 years.

resultsSix distinct BMI development groups were identified. Compared to the stable normal BMI group, the accelerated increasing BMI group exhibited reduced pre- and post-bronchodilator forced expiratory volume in 1 s (FEV

conclusionsEarly interventions aiming for normal BMI during childhood may contribute to improved lung health later in life.

Indexed as

Body Mass IndexLungSpirometryAdolescentAdultBirth CohortChildChild, PreschoolFemaleForced Expiratory VolumeHumansInfantInfant, NewbornMaleProspective StudiesRespiratory Function Tests

Identifiers

PMID39467611
PMCPMC11694551

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.