ArticleThe European respiratory journal2025
20-year trends in excess costs of COPD.
Article in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Astegolimab for chronic obstructive pulmonary disease with frequent exacerbations: pooled analysis of the ALIENTO and ARNASA trials.American journal of respiratory and critical care medicine · 2026Trial
- Historical Drug Costs Among Elderly Patients Hospitalized with Heart Failure in Canada, 2013-2014 to 2018-2019.CJC open · 2026Article
- Spatial transcriptomics reveals airway remodelling and molecular targets across COPD severity.ERJ open research · 2026Article
- Article
- Multimodal data-driven multitask learning for enhanced identification and classification of chronic obstructive pulmonary disease: a retrospective study.Journal of global health · 2026Article
- Short-Term Effects of Dupilumab in Eosinophilic COPD.Journal of clinical medicine · 2026Article
- LAMC2 Drives Airway Remodeling in COPD via EMT Regulation Through the AKT Pathway.International journal of chronic obstructive pulmonary disease · 2026Article
- Research Hotspots and Future Trends of Oxygen Therapy for COPD: A Bibliometric and Visualization Analysis from 1973 to 2024.International journal of chronic obstructive pulmonary disease · 2026Article
- Healthcare Costs and Trends of Multimorbidity in COPD Patients: A Population-Based Study in Singapore.International journal of chronic obstructive pulmonary disease · 2026Article
- PulmoClass-3DAtt: A Self-Attention Network for Classification of COPD, PRISm and Normal.International journal of chronic obstructive pulmonary disease · 2026Article
- Development and Internal Validation of a Prediction Model for Major Cardiovascular and Respiratory Events in Chronic Obstructive Pulmonary Disease: Nationwide Primary Care Electronic Medical Records Cohort Study.Pragmatic and observational research · 2026Article
- Integrating Disease Burden and Cost-Effectiveness for Value-Based Prioritisation of COPD Interventions: A Narrative Review.International journal of chronic obstructive pulmonary disease · 2026Review
- Frailty in older adults with chronic obstructive pulmonary disease: preliminary findings of prevalence and care priorities.BMC geriatrics · 2025Article
- Succinate-driven PKM2 succinylation and dimerization accelerates age-associated cardiac fibrosis.Communications biology · 2025Article
- The COPD risk associated with adulthood weight change and early adulthood BMI: a prospective cohort study.BMC public health · 2025Article
- Job Satisfaction of Registered Respiratory Therapists in Primary Care: Addressing Recruitment and Retention in Ontario and Manitoba.Behavioral sciences (Basel, Switzerland) · 2025Article
- Linking Lipid Metabolism and Immune Function: New Insights into Chronic Respiratory Diseases.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- Carbonaceous particle exposure triggered accumulation of Osteopontin/SPP1+ macrophages contributes to emphysema development.MedComm · 2025Article
- Burden of chronic obstructive pulmonary disease in China from 1990 to 2021: a population-based study.Frontiers in medicine · 2025Article
- The impact of health literacy on treatment adherence in COPD patients: chain mediation roles of self-efficacy and perceived disease threat.Frontiers in public health · 2025Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral major risk factors for COPD, such as population ageing, smoking rates and air pollution levels, are rapidly changing, causing inevitable changes in the population burden of COPD. We determined the excess direct costs of COPD and their trend from 2001 to 2020.
methodsUsing administrative health data from British Columbia, Canada, we created a retrospective matched cohort of physician-diagnosed COPD patients and non-COPD individuals. Excess direct medical costs (in 2020 Canadian dollars (CAD)) were estimated by analysing hospital records, outpatient services, medications and community care services. Comorbidity classes were assessed using International Classification of Diseases codes. Excess COPD costs were estimated as the adjusted difference in direct medical costs between the COPD and non-COPD cohorts.
resultsThere were 208 554 and 404 703 individuals in the COPD and non-COPD cohorts, respectively (47.8% female; mean baseline age 69.1 and 68.2 years, respectively). Direct medical costs for COPD were CAD 9224 per patient-year compared to CAD 3396 per patient-year for non-COPD, giving rise to excess costs of CAD 5828 (95% CI 5759-5897) per patient-year. Excess costs increased by 48% over the study period. Excess costs due to comorbidities were CAD 3588 (95% CI 3554-3622) per patient-year, with cardiovascular-related conditions alone exceeding the costs attributed to COPD (CAD 1375
conclusionsDespite multifaceted prevention and management initiatives, COPD-related economic burden is increasing, with the majority of costs due to comorbid conditions. Rising per-patient costs, combined with the flat or increasing prevalence of COPD in many jurisdictions, indicates a significant increase in COPD burden.
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