Evidence map›Paper›PMID 39467571›Full record

ArticleNature2024

A human isolate of bovine H5N1 is transmissible and lethal in animal models.

Chunyang Gu, Tadashi Maemura, Lizheng Guan, Amie J Eisfeld, Asim Biswas, Maki Kiso, Ryuta Uraki, Mutsumi Ito, Sanja Trifkovic, Tong Wang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Review
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  15. Quantitative Microbial Risk Assessment of Human H5N1 Infection From Consumption of Fluid Cow's Milk.Risk analysis : an official publication of the Society for Risk Analysis · 2026
    Article
  16. Article
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  19. Lack of respiratory droplet transmission of two recent human influenza A(H5N1) viruses in female ferrets.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2026
    Article
  20. Article

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Chunyang Gu *Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Tadashi Maemura *Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Lizheng Guan *Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Amie J Eisfeld *Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Asim Biswas *Influenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Maki Kiso *Department of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Ryuta UrakiDepartment of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.ORCID 0000-0003-0890-1922
Mutsumi ItoDepartment of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Sanja TrifkovicInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Tong WangInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Lavanya BabujeeInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Robert PreslerInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Randall DahnInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Yasuo SuzukiDepartment of Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan.
Peter J HalfmannInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-1648-1625
Seiya YamayoshiDepartment of Virology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.ORCID 0000-0001-7768-5157
Gabriele NeumannInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Yoshihiro KawaokaInfluenza Research Institute, Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, WI, USA. yoshihiro.kawaoka@wisc.edu.ORCID 0000-0001-5061-8296

Funding

NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00014 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2021 to 2025
$62.6M
NIAID NIH HHS 75N93021C00014
6 · The paper itself

Abstract

The outbreak of clade 2.3.4.4b highly pathogenic avian influenza viruses of the H5N1 subtype (HPAI H5N1) in dairy cattle in the USA has so far resulted in spillover infections of at least 14 farm workers

Indexed as

Disease Models, AnimalFerretsInfluenza A Virus, H5N1 SubtypeInfluenza, HumanOrthomyxoviridae InfectionsAnimalsCattleFemaleHumansMaleMiceRNA-Dependent RNA PolymeraseVirus ReplicationRNA-Dependent RNA Polymerase

Identifiers

PMID39467571
PMCPMC12629513

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.