Evidence map›Paper›PMID 39467029›Full record

ArticleNMR in biomedicine2025

Pathological tissue changes in brain tumors affect the pH-sensitivity of the T1-corrected apparent exchange dependent relaxation (AREX) of the amide protons.

Eike Steidl, Elisabeth Neuhaus, Manoj Shrestha, Ralf Deichmann, Katharina Weber, Joachim P Steinbach, Ulrich Pilatus, Elke Hattingen, Jan Rüdiger Schüre

Abstract read
In one paragraph

Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eike SteidlUniversity Hospital, Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.ORCID 0000-0001-7464-0236
Elisabeth NeuhausUniversity Hospital, Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.
Manoj ShresthaBrain Imaging Center, Goethe University Frankfurt, Frankfurt, Germany.
Ralf DeichmannBrain Imaging Center, Goethe University Frankfurt, Frankfurt, Germany.
Katharina WeberUniversity Hospital, University Cancer Center (UCT), Goethe University Frankfurt, Frankfurt, Germany.
Joachim P SteinbachUniversity Hospital, Institute of Neurooncology, Goethe University Frankfurt, Frankfurt, Germany.
Ulrich PilatusUniversity Hospital, Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.
Elke HattingenUniversity Hospital, Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.
Jan Rüdiger SchüreUniversity Hospital, Institute of Neuroradiology, Goethe University Frankfurt, Frankfurt, Germany.

Funding

Else Kröner-Fresenius-Stiftung
6 · The paper itself

Abstract

Measuring the intracellular pH (pHi) is of interest for brain tumor diagnostics. Common metrics of CEST imaging like the amide proton transfer-weighted (APTw) MTR

Indexed as

AmidesBrain NeoplasmsMagnetic Resonance ImagingProtonsAdultAgedFemaleHumansHydrogen-Ion ConcentrationMaleMiddle AgedAmidesProtonsAPT‐CESTAREXMR‐spectroscopypHT1‐relaxometry

Identifiers

PMID39467029
PMCPMC11602268

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.