Evidence map›Paper›PMID 39466980›Full record

ArticleJournal of surgical oncology2025

Liver Resection With Extrahepatic Disease: A Population-Based Analysis of Thoughtful Selection.

Kelly M Mahuron, Matthew C Hernandez, Paul Wong, Darrell Fan, Philip H G Ituarte, Mustafa Raoof, Gagandeep Singh, Yuman Fong, Laleh G Melstrom

Erratum issued Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07224724 (Exosome-derived Extrahepatic Metastasis Detection By Liquid Biopsy In Colorectal Cancer Liver Metastases), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07224724 recruitingnot on this map

Exosome-derived Extrahepatic Metastasis Detection By Liquid Biopsy In Colorectal Cancer Liver Metastases

TypeobservationalSponsorCity of Hope Medical CenterRan2024 to 2028Enrolled500ConditionsColorectal Cancer Liver Metastases (CRLM), Metastatic Colorectal Carcinoma (mCRC)ArmsEXELION
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kelly M MahuronDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California, USA.
Matthew C HernandezDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California, USA.ORCID http://orcid.org/0000-0001-8579-2702
Paul WongDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California, USA.
Darrell FanDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California, USA.
Philip H G ItuarteDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California, USA.
Mustafa RaoofDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California, USA.ORCID http://orcid.org/0000-0003-4710-2226
Gagandeep SinghDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California, USA.
Yuman FongDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California, USA.ORCID http://orcid.org/0000-0002-8934-9959
Laleh G MelstromDivision of Surgical Oncology, Department of Surgery, City of Hope National Medical Center, Duarte, California, USA.ORCID http://orcid.org/0000-0001-6279-7981

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe oncologic benefit of liver resection for colorectal liver metastases (CRLM) in the setting of concurrent extrahepatic disease (EHD) is controversial. We performed a population-based, cross-sectional study to determine the practice patterns and overall survival (OS) of patients with CRLM + EHD who underwent liver resection.

methodsPatients with CRLM + EHD were identified using the California Cancer Registry from 2000 to 2019. Records were linked to the Office of Statewide Health Planning Inpatient Database. Patient demographics, clinical characteristics, and survival were compared between CRLM + EHD patients with and without liver resection.

resultsOf 170 978 patients with CRLM, 62 003 (36%) had concurrent EHD (CRLM + EHD). In all, 3736 (6%) of CRLM + EHD underwent liver resection compared to 22% of patients with liver limited CRLM. Compared to CRLM + EHD without liver resection, CRLM + EHD with resection were younger, had fewer comorbidities, received higher frequencies of perioperative chemotherapy, and were more likely to have only a single site of EHD rather than multiple sites. Median OS was significantly higher for CRLM + EHD with resection compared to without (52 vs. 27 months, HR 0.46 [95% CI 0.44-0.47], p < 0.001). Regarding the location of EHD, this survival benefit was observed with liver resection for lung, peritoneal, intraabdominal lymph nodes, ovarian, and bone metastases.

conclusionsIn a large population-based setting, subsets of CRLM + EHD patients that undergo liver resection are associated with prolonged survival. These results support surgery with thoughtful patient selection to optimize survival outcomes in this population.

Indexed as

Colorectal NeoplasmsHepatectomyLiver NeoplasmsPatient SelectionAdultAgedCaliforniaCross-Sectional StudiesFemaleFollow-Up StudiesHumansMaleMiddle AgedRegistriesSurvival Ratecolorectal liver metastasisextrahepatic diseaseliver resectionpatient selection

Identifiers

PMID39466980
PMCPMC12044278

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.