ArticleJournal of veterinary internal medicine
Metabolomic fingerprinting of milk fever cows: Pre- and postpartum metabolite alterations.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- From Parts to Whole: A Systems Biology Approach to Decoding Milk Fever.Veterinary sciences · 2025Review
- Untargeted plasma metabolomics based on liquid chromatography-mass spectrometry for the analysis ofFrontiers in veterinary science · 2025Article
- Metabolomic fingerprinting of milk fever cows: Pre- and postpartum metabolite alterations.Journal of veterinary internal medicineArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundMilk fever (MF), a metabolic disorder in dairy cows characterized by low blood calcium concentrations postpartum, is well-recognized clinically. However, comprehensive data on the alteration of metabolites associated with this condition remains sparse. HYPOTHESIS: Delineate serum metabolite profiles and metabolic pathways preceding, coinciding with, and after the onset of MF. ANIMALS: Twenty-six cows, including 20 healthy cows and 6 cows initially affected by MF. Because of culling, the number of MF-affected cows decreased to 4 at MF week, +4 weeks, and +8 weeks postpartum.
methodsA nested case-control longitudinal study was conducted, with blood samples collected at -8 and -4 weeks prepartum, MF week, and +4 and +8 weeks postpartum. Serum analysis utilized direct injection/liquid chromatography/tandem mass spectrometry (DI/LC/MS/MS) techniques.
resultsKey findings included the identification of diverse metabolites such as hexose, amino acids, phosphatidylcholines, lysophosphatidylcholines, and sphingomyelin, which varied between studied groups (P < .05). The most marked metabolic alterations were observed 4 weeks prepartum. In total, 42, 56, 38, 29, and 24 metabolites distinguished the MF group at the respective time points (P < .05). Additionally, 33 metabolic pathways, including amino acid, antioxidant metabolism, fatty acid degradation, and carbohydrate processing, were impacted (P < .05). CONCLUSIONS AND CLINICAL IMPORTANCE: Metabolic disruptions in dairy cows begin several weeks before the clinical manifestation of MF and persist up to 8 weeks postpartum. These findings emphasize the complexity of MF, extending beyond only hypocalcemia and indicate the necessity for preemptive monitoring in dairy herd management.
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