Evidence map›Paper›PMID 39466653›Full record

Trial reportMolecular nutrition & food research2024

Serum Concentrations of Folate Forms Following Supplementation of Multimicronutrients with 400 µg or 800 µg Mix of (6S)-5-Methyltetrahydrofolate and Folic Acid (1:1) in Women of Childbearing Age.

Rima Obeid, Elena Rube, Christiane Schön, Jürgen Geisel

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Molecular nutrition & food research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Rima ObeidDepartment of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, D-66420, Homburg/Saar, Germany.ORCID 0000-0002-0064-7029
Elena RubeDepartment of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, D-66420, Homburg/Saar, Germany.
Christiane SchönBioTeSys GmbH, Schelztor Street 54-56, D-73728, Esslingen, Germany.
Jürgen GeiselDepartment of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, D-66420, Homburg/Saar, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

scopeA mixture of (6S)-5-methyltetrahydrofolate-calcium salt ((6S)-5-MTHF-Ca) and folic acid (FA) from multimicronutrient supplements may show a dose-dependent effect on serum folate concentrations. METHODS AND

resultsThe study compares fasting concentrations of serum folate spices after 8 weeks of either 400 or 800 µg day

conclusionsSupplementation of multimicronutrients with 800 µg folate mix for 8 weeks causes higher serum (6S)-5-MTHF concentrations, but not a higher prevalence of detectable FA compares to 400 µg folate.

Indexed as

Dietary SupplementsFolic AcidTetrahydrofolatesAdultFemaleHumansMiddle AgedYoung Adult5-methyltetrahydrofolateFolic AcidTetrahydrofolatesfolic acidmethylfolatepregnancyserum folatesupplements

Identifiers

PMID39466653
PMCPMC11605785

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.