ArticleClinical and experimental nephrology2025
Estimated glomerular filtration rate versus creatinine clearance to determine anticoagulant dosage after lower-limb orthopedic surgery.
Article in Clinical and experimental nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- When the Heart and Hip Collide: The Interplay Between Atrial Fibrillation and Neck of Femur Fractures.Journal of cardiovascular development and disease · 2026Review
- Interpretable machine learning analysis of the impact of tranexamic acid combined with antibiotics on renal function and its risk factors in hip replacement surgeries.Frontiers in surgery · 2026Article
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Authors and funding
9 authors.
Funding
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Abstract
backgroundAnticoagulation is recommended for thromboprophylaxis after lower-limb orthopedic surgery. The suggested dosage is based on creatinine clearance (CCr) in the labels. However, most facilities only provide estimated glomerular filtration rate (eGFR) as laboratory data. Because the eGFR equation adjusts for a body surface area (BSA) of 1.73 m
methodsThis study included patients who underwent lower-limb orthopedic surgery and received anticoagulants (edoxaban, enoxaparin, and fondaparinux) between 2017 and 2020 at Yaizu City Hospital. Anticoagulant dosing was evaluated using CCr, eGFR, and de-indexed eGFR (without correction for BSA), and the incidences of VTE and bleeding were compared among these formulas.
resultsThe median values for BSA, CCr, eGFR, and de-indexed eGFR were 1.40 m
conclusionsIn orthopedic surgery, anticoagulant dosages should be based on CCr for patients with a small BSA to avoid bleeding risks.
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