Evidence map›Paper›PMID 39466576›Full record

ArticleMolecular neurobiology2025

Huang-Pu-Tong-Qiao Formula Alleviates Hippocampal Neuron Damage by Inhibiting NLRP3 Inflammasome-mediated Pyroptosis in Alzheimer's Disease.

Nan Shao, Zhixian Ding, Fei Liu, Xiaoyan Zhang, Xiaojuan Wang, Shenglin Hu, Shu Ye, Tingting Wang, Wenwen Si, Biao Cai

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nan Shao *College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Zhixian Ding *College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Fei Liu *College of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Xiaoyan ZhangCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Xiaojuan WangCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Shenglin HuCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Shu YeCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Tingting WangCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China.
Wenwen SiCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China. siwenwen2008@163.com.
Biao CaiCollege of Integrated Chinese and Western Medicine, Anhui University of Chinese Medicine, Hefei, 230012, China. caibiao@ahtcm.edu.cn.ORCID http://orcid.org/0000-0002-3375-0073

Funding

the Discipline (Major) Top Talents Academic Support Project for Anhui Universities gxbjZD2022024the National Natural Science Foundation of China 81873351the National Natural Science Foundation of China 82104570the Natural Science Foundation of Anhui province 2308085MH295the Natural Science Research Project for Anhui Universities KJ2021A0589
6 · The paper itself

Abstract

Huang-Pu-Tong-Qiao (HPTQ), a Traditional Chinese Medicine formula, has achieved remarkable efficacy in clinically treating Alzheimer's disease (AD). Pyroptosis refers to the inflammatory necrosis of cells, which contributes to AD pathological progression. However, it is unclear whether the therapeutic effect of HPTQ on AD is related to reducing pyroptosis. In this study, the network pharmacology analysis was used to predict the molecular mechanism of HPTQ in treating AD and validated our hypothesis through mice and cell experiments. APP/PS1 transgenic mice and Aβ

Indexed as

Alzheimer DiseaseDrugs, Chinese HerbalHippocampusInflammasomesNeuronsNLR Family, Pyrin Domain-Containing 3 ProteinPyroptosisAmyloid beta-PeptidesAnimalsCell LineMaleMiceMice, Inbred C57BLMice, TransgenicAmyloid beta-PeptidesDrugs, Chinese HerbalInflammasomesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseAlzheimer’s diseaseHuang-Pu-Tong-QiaoNetwork pharmacologyNLRP3 inflammasomePyroptosisTraditional Chinese medicine

Identifiers

PMID39466576

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.