Evidence map›Paper›PMID 39466518›Full record

ArticleMedical & biological engineering & computing2025

Structural design and biomechanical analysis of a combined titanium and polyetheretherketone cage based on PE-PLIF fusion.

Lei Ma, Yutang Xie, Kai Zhang, Jing Chen, Yanqin Wang, Liming He, Haoyu Feng, Weiyi Chen, Meng Zhang, Yanru Xue and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Medical & biological engineering & computing, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. DASNet: A Convolutional Neural Network with SE Attention Mechanism for ccRCC Tumor Grading.Interdisciplinary sciences, computational life sciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lei MaTaiyuan University of Technology School of Biomedical Engineering, Taiyuan, China.
Yutang XieTaiyuan University of Technology School of Biomedical Engineering, Taiyuan, China.
Kai ZhangHuajin Orthopaedic Hospital, Taiyuan, 030024, China.
Jing ChenTaiyuan University of Technology School of Biomedical Engineering, Taiyuan, China.
Yanqin WangTaiyuan University of Technology School of Biomedical Engineering, Taiyuan, China.
Liming HeShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Haoyu FengShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China.
Weiyi ChenTaiyuan University of Technology School of Biomedical Engineering, Taiyuan, China.
Meng ZhangTaiyuan University of Technology School of Biomedical Engineering, Taiyuan, China. zhangmeng03@tyut.edu.cn.
Yanru XueTaiyuan University of Technology School of Biomedical Engineering, Taiyuan, China.
Xiaogang WuTaiyuan University of Technology School of Biomedical Engineering, Taiyuan, China. wuxiaogangtyut@163.com.ORCID http://orcid.org/0000-0003-3220-8933
Qiang LiShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, 030032, China. luysonly@163.com.

Funding

China Postdoctoral Science Foundation 2020M680913Natural Science Foundation of Shanxi Province 12272250Natural Science Foundation of Shanxi Province 12372310The Shanxi Scholarship council of China 2022-081
6 · The paper itself

Abstract

In lumbar spinal fusion, the titanium cage tends to cause stress shielding due to their high elastic modulus, which can lead to degenerative lesions in adjacent spinal segments. Furthermore, polyetheretherketone (PEEK) cages have certain material characteristics that do not promote bone ingrowth and fusion stability. In this study, a new cage was designed, and its biomechanical performance in percutaneous endoscopic posterior lumbar interbody fusion (PE-PLIF) was analyzed using the finite element (FE) method. A complete model of the L4-L5 lumbar spine was established, and static and harmonic vibration FE analysis models were developed based on it. The biomechanical properties of titanium, PEEK, and combined cage in PE-PLIF fusion were compared. The strain capacity of the combined fusion increased by 9.5% when compared to the titanium fusion. The surgical model under the combined fusion reduces the L5 endplate stress by 12% in the forward flexion condition and the fusion stress by 17% in the vibration condition compared to the model supported by the titanium fusion, and the differences in screw stress and mobility among the three models are not significant in multiple conditions. Consequently, the combined cage demonstrates a certain reduction in the stress-shielding effect when compared to the titanium cage; it has better fusion effect and provides theoretical support and guidance for the design of the clinical fusion cage.

Indexed as

KetonesPolyethylene GlycolsSpinal FusionTitaniumBenzophenonesBiomechanical PhenomenaFinite Element AnalysisHumansLumbar VertebraePolymersStress, MechanicalBenzophenonesKetonespolyetheretherketonePolyethylene GlycolsPolymersTitaniumCombined cage designFinite element methodPE-PLIFSimple harmonic vibrationStress shielding

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.