Evidence map›Paper›PMID 39466444›Full record

Observational studyClinical research in cardiology : official journal of the German Cardiac Society2025

Echocardiographic left atrial stiffness index predicts high left ventricular filling pressures in patients with acute heart failure: an observational study.

Massimiliano Camilli, Ludovica Amore, Federico Ballacci, Giulia Iannaccone, Marco Giuseppe Del Buono, Federica Giordano, Francesca Graziani, Tommaso Sanna, Daniela Pedicino, Francesco Burzotta and 8 more

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Massimiliano CamilliDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy. massimiliano.camilli1@policlinicogemelli.it.ORCID http://orcid.org/0000-0002-2940-5349
Ludovica AmoreDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Federico BallacciDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.
Giulia IannacconeDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.
Marco Giuseppe Del BuonoDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.
Federica GiordanoDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.
Francesca GrazianiDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Tommaso SannaDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.
Daniela PedicinoDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Francesco BurzottaDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.
Carlo TraniDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.
Gaetano Antonio LanzaDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.
Rocco Antonio MontoneDepartment of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
Nadia AspromonteDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.
Laura LupiCardiology, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Marianna AdamoCardiology, ASST Spedali Civili di Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Filippo CreaDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.
Antonella LombardoDepartment of Cardiovascular and Pulmonary Sciences, Catholic University of the Sacred Heart, Largo Agostino Gemelli, 00168, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn acute heart failure (AHF) patients, non-invasive estimation of left ventricular filling pressures (LVFPs) appears crucial to guide management. Although poorly investigated, left atrial (LA) mechanics play a pivotal role in this setting. This report sought to assess the correlation of echocardiographic LA stiffness index with invasive LVFPs and its diagnostic accuracy as compared to other parameters used in clinical practice.

methodsIn this observational, prospective study, 104 patients with suspected acute coronary syndrome and signs/symptoms of AHF were enrolled. Available invasive estimation of LVFPs was required. Comprehensive echocardiography was performed for all patients, including LA reservoir strain (LARS). LA stiffness index was derived by speckle-tracking analysis and Tissue Doppler imaging as early diastolic transmitral inflow velocity/mitral annulus early diastolic velocity [E/e']/LARS.

resultsInvasively measured LVFPs showed a strong correlation with LA stiffness index (Spearman ρ = 0.773, p < 0.0001), as well as with LARS and E/e'. Receiver operating characteristic (ROC) curve analysis was used to demonstrate better accuracy performed by LA stiffness index than average E/e', LA volume or LARS alone, in predicting high LVFPs. Guideline-recommended assessment of diastolic function was finally compared to LARS and LA stiffness index performances in an independent population group; we were hence able to obtain a LA stiffness threshold of 0.48 with a positive predictive value of 91.7% and a negative predictive value of 88.9% in identifying patients with high LVFPs.

conclusionsFor the first time, diagnostic performance of LA stiffness index has been investigated in a heterogeneous AHF population, providing correlations with invasively measured LVFPs and comparisons with established diastolic function metrics.

Indexed as

Atrial Function, LeftEchocardiography, DopplerHeart AtriaHeart FailureStroke VolumeVentricular Function, LeftVentricular PressureAcute DiseaseAgedFemaleHumansMaleMiddle AgedPredictive Value of TestsProspective StudiesROC CurveAcute heart failureEchocardiographyLeft atrial stiffnessLeft ventricular filling pressuresSpeckle tracking

Identifiers

PMID39466444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.