Evidence map›Paper›PMID 39466441›Full record

ReviewNaunyn-Schmiedeberg's archives of pharmacology2025

Emerging insights into the role of natural products and miRNAs in psoriasis: from pathophysiology to precision medicine.

Osama A Mohammed, Mushabab Alghamdi, Emad Bahashwan, AbdulElah Al Jarallah AlQahtani, Adel Alfaifi, Rania H Hassan, Jaber Alfaifi, Mohannad Mohammad S Alamri, Abdullah Hassan Alhalafi, Masoud I E Adam and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Osama A MohammedDepartment of Pharmacology, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
Mushabab AlghamdiDepartment of Internal Medicine, Division of Rheumatology, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
Emad BahashwanDepartment of Internal Medicine, Division of Dermatology, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
AbdulElah Al Jarallah AlQahtaniDepartment of Internal Medicine, Division of Dermatology, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
Adel AlfaifiDepartment of Dermatology, Armed Forces Hospital - Southern Region, 62413, Khamis Mushait, Saudi Arabia.
Rania H HassanDermatology Clinic, Abbasseya Psychiatric Hospital, Abbasseya, Cairo, 11517, Egypt.
Jaber AlfaifiDepartment of Child Health, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
Mohannad Mohammad S AlamriDepartment of Family and Community Medicine, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
Abdullah Hassan AlhalafiDepartment of Family and Community Medicine, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
Masoud I E AdamDepartment of Medical Education and Internal Medicine, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
Waad Fuad BinAfifDepartment of Internal Medicine, College of Medicine, University of Bisha, 61922, Bisha, Saudi Arabia.
Mustafa Ahmed Abdel-ReheimDepartment of Pharmacology, College of Pharmacy, Shaqra University, 11961, Shaqra, Saudi Arabia. m.ahmed@su.edu.sa.ORCID 0000-0002-7728-0923
Sherif S Abdel MageedPharmacology and Toxicology Department, Faculty of Pharmacy, Badr University in Cairo (BUC), Cairo, Badr City, 11829, Egypt.
Ahmed S DoghishDepartment of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Cairo, Badr City, , 11829, Egypt. ahmed_doghish@azhar.edu.eg.ORCID 0000-0002-0136-7096

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psoriasis is a sustainable skin disease characterized by inflammation resulting from the interaction between immune cells and keratinocytes. Significant advancements have been achieved in studying the molecular process behind noncoding and coding genes, leading to valuable insights for clinical therapy. Nevertheless, our comprehension of this intricate ailment remains ambiguous. Natural products such as curcumin, vitamin D, omega-3, vitamin E, psoralen, gallic acid (GA), and resveratrol offer a promising alternative or adjunct therapy for psoriasis by modulating multiple pathways and exhibiting fewer side effects compared to conventional treatments. MicroRNAs (miRNAs) are short RNAs that are involved in regulating gene expression after transcription, namely by suppressing gene activity. Recent research on miRNAs has uncovered their significant significance in the development of psoriasis. In this review, we examined the latest developments in the investigation of miRNAs in psoriasis. Previous studies have revealed that imbalanced miRNAs in psoriasis have a significant impact on the processes of keratinocyte differentiation, proliferation, and the progression of inflammation. Furthermore, miRNAs exert an impact on the activity of immune cells involved in psoriasis, such as Langerhans cells, dendritic cells, and CD4

Indexed as

Biological ProductsMicroRNAsPsoriasisAnimalsHumansKeratinocytesPrecision MedicineBiological ProductsMicroRNAsImmune systemmiRNAPsoriasis

Identifiers

PMID39466441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.