Evidence map›Paper›PMID 39466369›Full record

ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2025

The international expert consensus on management of external auditory canal carcinoma.

Pei Zhou, Rubens de Brito, Yong Cui, Simon Lloyd, Henricus Kunst, J Walter Kutz, Navin Mani, In Seok Moon, Badr Eldin Mostafa, Cindy Nabuurs and 4 more

Abstract readConsensus StatementReview
PubMed Publisher
In one paragraph

Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pei ZhouDepartment of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Rubens de BritoDepartment of Otorhinolaryngology, University of São Paulo School of Medicine, São Paulo, Brazil.
Yong CuiDepartment of Otolaryngology-Head and Neck Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Simon LloydUniversity Department of Otolaryngology Head and Neck Surgery, Peter Mount House, Manchester Royal Infirmary, Manchester, UK.
Henricus KunstDepartment of Otorhinolaryngology, Hearing and Genes, Radboud University Medical Center, Nijmegen, The Netherlands.
J Walter KutzDepartment of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Navin ManiDepartment of Otolaryngology, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
In Seok MoonDepartment of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Korea.
Badr Eldin MostafaDepartment of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Ain-Shams University, Cairo, Egypt.
Cindy NabuursDepartment of Otorhinolaryngology, Hearing and Genes, Radboud University Medical Center, Nijmegen, The Netherlands.
Sampath Chandra Prasad RaoDepartment of Otolaryngology, Kasturba Medical College, Manipal University, Head & Neck Surgery, Mangalore, Karnataka, India.
Bingbin XieDepartment of Otolaryngology Head and Neck Surgery, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
Yibo ZhangDepartment of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China.
Chunfu DaiDepartment of Otology and Skull Base Surgery, Eye Ear Nose and Throat Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, China. cfdai66@126.com.ORCID http://orcid.org/0000-0002-6948-7289

Funding

National Natural Science Foundation of China 82171142Shanghai Municipal key clinical specialty shslczdzk00801
6 · The paper itself

Abstract

purposeThe objective of this consensus is to provide otolaryngologists with appropriate strategies in the management of external auditory canal (EAC) carcinoma.

methodsIn the absence of randomized controlled trials, the consensus is based on expert opinions utilizing the Rand/UCLA appropriateness method [Fitch and Aguilar in The RAND/UCLA appropriateness method user's manual, RAND Corporation, Santa Monica, CA, 2001], drawing from existing literature and clinical experience.

resultsThe management recommendations are structured around 12 key areas, including: definition and pathology, pathogenesis, clinical manifestations, work-up, tumor staging system, surgical management of primary tumor, surgical management of the parotid gland and the temporomandibular joint, lymph node metastasis, radiotherapy, chemotherapy, reconstruction, and follow-up.

conclusionManagement strategies for EAC carcinoma rely on tumor extension and histopathological features. Surgical removal with free surgical margins or combination with radiotherapy, chemotherapy are most often the best options. Given the rarity of the disease, prospective, randomized, multi-institutional clinical trials should be designed to enable reliable comparisons of the outcomes of EAC carcinoma treatments, thereby providing evidence-based clinical data to establish widely accepted guidelines. It emphasizes the need for a multidisciplinary team to be involved in the management of EAC carcinoma, and regular follow-up should be implemented postoperatively.

Indexed as

CarcinomaEar CanalEar NeoplasmsCombined Modality TherapyHumansNeoplasm StagingClinical practice guidelinesExpert consensusExternal auditory canal carcinomaTemporal bone

Identifiers

PMID39466369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.