ArticleeLife2024
Regional response to light illuminance across the human hypothalamus.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Review
- Cortical excitability is affected by light exposure - Distinct effects in adolescents and young adults.Neurobiology of sleep and circadian rhythms · 2026Article
- Article
- Human Cerebral Blood Flow Activity with Diurnal Variation Differentially Correlated with the Suprachiasmatic Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- How light reshapes the mind. An active inference framework for the cognitive and emotional effects of indoor lighting.Frontiers in computational neuroscience · 2026Article
- Regional activity within the human amygdala varies with season, mood and illuminance.Nature communications · 2025Article
- Relationships between light exposure and aspects of cognitive function in everyday life.Communications psychology · 2025Article
- Bridging Gaps in Sundown Syndrome Research: a Scoping Review and Roadmap for Future Multimodal Approaches.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Article
- Outdoor light spending time, genetic predisposition and incident Parkinson's disease: the mediating effect of lifestyle and vitamin D.Journal of health, population, and nutrition · 2025Article
- How natural light influences HSR drivers' visual behavior.Frontiers in public health · 2025Article
- Research progress on the neural mechanism of light therapy improving cognitive function in depression: from retinal projections to neuroplasticity.Frontiers in neurologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Light exerts multiple non-image-forming biological effects on physiology including the stimulation of alertness and cognition. However, the subcortical circuitry underlying the stimulating impact of light is not established in humans. We used 7 Tesla functional magnetic resonance imaging to assess the impact of variations in light illuminance on the regional activity of the hypothalamus while healthy young adults (N=26; 16 women; 24.3±2.9 y) were completing two auditory cognitive tasks. We find that, during both the executive and emotional tasks, higher illuminance triggered an activity increase over the posterior part of the hypothalamus, which includes part of the tuberomamillary nucleus and the posterior part of the lateral hypothalamus. In contrast, increasing illuminance evoked a decrease in activity over the anterior and ventral parts of the hypothalamus, encompassing notably the suprachiasmatic nucleus and another part of the tuberomammillary nucleus. Critically, the performance of the executive task was improved under higher illuminance and was negatively correlated with the activity of the posterior hypothalamus area. These findings reveal the distinct local dynamics of different hypothalamus regions that underlie the impact of light on cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.