Evidence map›Paper›PMID 39466174›Full record

ArticleAlcohol, clinical & experimental research2024

Insomnia treatment effects on negative emotionality among veterans in treatment for alcohol use disorder.

Mary Beth Miller, Ryan W Carpenter, Melissa Nance, Lindsey K Freeman, Jane Metrik, Brian Borsari, Christina S McCrae, Jennifer E Merrill, Kate B Carey, John E McGeary

Registry-linked trialAbstract read
In one paragraph

Article in Alcohol, clinical & experimental research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03806491 (The Impact of CBT for Insomnia on Alcohol Treatment Outcomes Among Veterans), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03806491 nacompletednot on this map

The Impact of CBT for Insomnia on Alcohol Treatment Outcomes Among Veterans

TypeinterventionalSponsorUniversity of Missouri-ColumbiaRan2019 to 2022Enrolled67ConditionsInsomnia, Alcohol Use DisorderArmsCognitive Behavioral Therapy for Insomnia, Sleep Hygiene, Alcohol Use Disorder Treatment as Usual
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mary Beth MillerUniversity of Missouri, Columbia, Missouri, USA.ORCID https://orcid.org/0000-0003-0624-1414
Ryan W CarpenterUniversity of Notre Dame, Notre Dame, Indiana, USA.ORCID https://orcid.org/0000-0002-1351-7071
Melissa NanceUniversity of Notre Dame, Notre Dame, Indiana, USA.
Lindsey K FreemanUniversity of Missouri, Columbia, Missouri, USA.
Jane MetrikBrown University School of Public Health, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0001-9727-3838
Brian BorsariSan Francisco VA Health Care System, San Francisco, California, USA.
Christina S McCraeUniversity of South Florida College of Nursing, Tampa, Florida, USA.
Jennifer E MerrillBrown University School of Public Health, Providence, Rhode Island, USA.ORCID https://orcid.org/0000-0002-8310-140X
Kate B CareyBrown University School of Public Health, Providence, Rhode Island, USA.
John E McGearyProvidence VA Medical Center, Providence, Rhode Island, USA.

Funding

Youth suicide risk: interplay of sleep behavior and circadian timing with self-critical rumination and self- reassuranceP20GM139743 · NIGMS · EMMA PENDLETON BRADLEY HOSPITAL · PI Sarah Ann Thomas · 2021 to 2026
$13.0M
The Impact of Insomnia Treatment on Heavy Alcohol Use among Returning VeteransK23AA026895 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI MILLER, MARY ELIZABETH · 2019 to 2023
$896k
Developing a modified brief alcohol-focused intervention tailored for patients with alcohol use disorder in opioid agonist treatmentK23AA029729 · NIAAA · UNIVERSITY OF NOTRE DAME · PI Ryan W Carpenter · 2022 to 2026
$793k
The Impact of CBT for Insomnia on Alcohol Treatment Outcomes among VeteransR21AA025715 · NIAAA · UNIVERSITY OF MISSOURI-COLUMBIA · PI MCGEARY, JOHN E, METRIK, JANE · 2018 to 2019
$417k
NIAAA NIH HHS K23 AA026895NIAAA NIH HHS K23AA026895NIAAA NIH HHS K23 AA029729NIAAA NIH HHS K23AA029729NIAAA NIH HHS R21 AA025715NIAAA NIH HHS R21AA025715NIGMS NIH HHS P20 GM139743NIGMS NIH HHS P20GM139743
6 · The paper itself

Abstract

backgroundInsomnia symptoms are pervasive and persistent in alcohol use disorder (AUD), though little is known about the mechanisms that underlie this association. We previously found that cognitive behavioral therapy for insomnia (CBT-I) reduced alcohol-related problems among veterans by improving insomnia severity (NCT03806491). In this planned secondary analysis of the same clinical trial data, we tested negative emotionality as one potential mechanism to explain this effect. Specifically, we tested the change in negative emotionality as a mediator of the association between change in insomnia symptoms and alcohol-related outcomes (craving, heavy drinking frequency, and alcohol-related problems).

methodsParticipants were 67 veterans in treatment for AUD who also met the criteria for insomnia disorder (91% male, 84% White, average age = 46.3 years). Participants were randomized to five sessions of CBT-I or a single-session sleep hygiene control. Assessments occurred at baseline, immediately posttreatment (~6 weeks after baseline), and at 6-week follow-up. Measures included the Insomnia Severity Index, Penn Alcohol Craving Scale, Timeline Followback, and Short Inventory of Problems. We created a latent negative emotionality indicator based on five validated and reliable measures of negative emotionality.

resultsContrary to hypotheses, CBT-I did not improve negative emotionality relative to sleep hygiene control. However, across both treatment conditions, decreases in insomnia symptoms from baseline to posttreatment were associated with concurrent decreases in negative emotionality, which in turn predicted reductions in alcohol craving and heavy drinking.

conclusionNegative emotionality may help explain links between insomnia symptoms and alcohol-related outcomes.

Indexed as

alcoholcognitive behavioral therapydepressionPTSDsleep

Identifiers

PMID39466174
PMCPMC11622692

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.