Evidence map›Paper›PMID 39466073›Full record

ArticleCancer research communications2024

Mathematical Modeling Unveils Optimization Strategies for Targeted Radionuclide Therapy of Blood Cancers.

Maxim Kuznetsov, Vikram Adhikarla, Enrico Caserta, Xiuli Wang, John E Shively, Flavia Pichiorri, Russell C Rockne

Abstract read
In one paragraph

Article in Cancer research communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Maxim KuznetsovDepartment of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, California.ORCID 0000-0002-0004-9002
Vikram AdhikarlaDepartment of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, California.ORCID 0000-0001-9747-4349
Enrico CasertaDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, California.ORCID 0009-0004-0255-0468
Xiuli WangDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, California.ORCID 0000-0001-5964-4327
John E ShivelyDepartment of Immunology and Theranostics, Beckman Research Institute, City of Hope National Medical Center, Duarte, California.ORCID 0000-0002-7763-770X
Flavia PichiorriDepartment of Hematologic Malignancies Translational Science, Beckman Research Institute, City of Hope National Medical Center, Duarte, California.ORCID 0000-0003-0427-6891
Russell C RockneDepartment of Computational and Quantitative Medicine, Beckman Research Institute, City of Hope National Medical Center, Duarte, California.ORCID 0000-0002-1557-159X

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI John Charles Williams · 1985 to 2026
$86.3M
Exploring the preclinical relevance of therapeutic radiolabeled daratumumab (anti-CD38) in combination with anti-CS1 CAR T cells as a novel combinatorial treatment for multiple myelomaR01CA238429 · NCI · BECKMAN RESEARCH INSTITUTE/CITY OF HOPE · PI PICHIORRI, FLAVIA, ROCKNE, RUSSELL CHRISTIAN · 2019 to 2023
$2.0M
NCI NIH HHS P30 CA033572NCI NIH HHS R01 CA238429
6 · The paper itself

Abstract

significanceMathematical modeling yields general principles for optimization of TRT in mouse models of multiple myeloma that can be extrapolated to other cancer models and clinical settings.

Indexed as

Multiple MyelomaAnimalsHematologic NeoplasmsHumansMiceModels, Theoretical

Identifiers

PMID39466073
PMCPMC11562018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.