Evidence map›Paper›PMID 39466030›Full record

ArticleThe Journal of general virology2024

Organotypic brain slices as a model to study the neurotropism of the highly pathogenic Nipah and Ebola viruses.

Michelle Gellhorn Serra, Lars Meier, Lucie Sauerhering, Jochen Wilhelm, Alexandra Kupke

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Michelle Gellhorn SerraPhilipps University Marburg, Institute of Virology, Marburg, Germany.
Lars MeierPhilipps University Marburg, Institute of Virology, Marburg, Germany.
Lucie SauerheringPhilipps University Marburg, Institute of Virology, Marburg, Germany.
Jochen WilhelmDepartment of Internal Medicine, Universities of Giessen and Marburg Lung Center, Member of the German Center for Lung Research, Giessen, Germany.
Alexandra KupkePhilipps University Marburg, Institute of Virology, Marburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nipah virus (NiV) and Ebola virus (EBOV) are highly pathogenic zoonotic viruses with case fatality rates of up to 90%. While the brain is a known target organ following NiV infection, involvement of the central nervous system in EBOV-infected patients only became more evident after the West African epidemic in 2013-2016. To gain a deeper comprehension of the neurotropism of NiV and EBOV with respect to target cells, affected brain regions and local inflammatory responses, murine organotypic brain slices (BS) were established and infected. Both NiV and EBOV demonstrated the capacity to infect BS from adult wt mice and mice lacking the receptor for type I IFNs (IFNAR

Indexed as

BrainCytokinesEbolavirusNipah VirusViral TropismAnimalsDisease Models, AnimalHemorrhagic Fever, EbolaHenipavirus InfectionsHumansMiceMice, Inbred C57BLMice, KnockoutReceptor, Interferon alpha-betaVirus ReplicationCytokinesReceptor, Interferon alpha-betachemokineschoroid plexuscytokinesEBOVneurotropismNiVorganotypic brain slices

Identifiers

PMID39466030
PMCPMC12453409

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.