ArticleJournal of magnetic resonance imaging : JMRI2025
Characterization of Brain Abnormalities in Lactational Neurodevelopmental Poly I:C Rat Model of Schizophrenia and Depression Using Machine-Learning and Quantitative MRI.
Article in Journal of magnetic resonance imaging : JMRI, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Cerebellar microglia-derived IL-17A mitigates autism-related behavioral and synaptic deficits.Molecular psychiatry · 2026Article
- Characterizing multivariate regional hubs for schizophrenia classification, sex differences, and brain age estimation using explainable AI.medRxiv : the preprint server for health sciences · 2025Article
- Exploratory MIA study: multimodal magnetic resonance imaging characteristics of rat offspring induced by maternal Poly(I:C) exposure during pregnancy.Frontiers in psychiatry · 2025Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundA recent neurodevelopmental rat model, utilizing lactational exposure to polyriboinosinic-polyribocytidilic acid (Poly I:C) leads to mimics of behavioral phenotypes resembling schizophrenia-like symptoms in male offspring and depression-like symptoms in female offspring. PURPOSE: To identify mechanisms of neuronal abnormalities in lactational Poly I:C offspring using quantitative MRI (qMRI) tools. STUDY TYPE: Prospective. ANIMAL MODEL: Twenty Poly I:C rats and 20 healthy control rats, age 130 postnatal day. FIELD STRENGTH/SEQUENCE: 7 T. Multiflip-angle FLASH protocol for T ASSESSMENT: Nursing dams were injected with the viral mimic Poly I:C or saline (control group). In adulthood, quantitative maps of T STATISTICAL TESTS: Random forest machine learning (ML) tool was employed to identify MRI markers of disease and classify Poly I:C rats from healthy controls based on quantitative features.
resultsPoly I:C rats were identified from controls with an accuracy of 82.5 ± 25.9% for females and 85.0 ± 24.0% for males. Poly I:C females exhibited differences mainly in diffusion-derived parameters in the thalamus and the medial prefrontal cortex (MPFC), while males displayed changes primarily in diffusion-derived parameters in the corpus callosum and MPFC. DATA
conclusionqMRI shows potential for identifying sex-specific brain abnormalities in the Poly I:C model of neurodevelopmental disorders. LEVEL OF EVIDENCE: NA TECHNICAL EFFICACY: Stage 2.
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