SynthesisEuropean journal of clinical investigation2025
Diabetes and the risk of cardiovascular events and all-cause mortality among older adults: an individual participant data analysis of five prospective studies.
Synthesis in European journal of clinical investigation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diabetes and the risk of cardiovascular events and all-cause mortality among older adults: an individual participant data analysis of five prospective studies.European journal of clinical investigation · 2025Pooled it
- Cardiovascular Diseases and All-Cause Mortality Risk in Patients With Prehypertension and Noncommunicable Diseases: Results From the Kailuan Study.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- Cardiovascular outcomes and mortality risk at diagnosis of type 2 diabetes in older adults: a retrospective population-based study using health records from Spain.EClinicalMedicine · 2026Article
- Article
- Development and validation of the CARE-DM model to predict the cardiovascular risk in older persons with type 2 diabetes.European journal of preventive cardiology · 2026Article
- Joint associations between exercising and classical cardiometabolic risk factors with all-cause, premature and cardiovascular mortality: a prospective cohort study among Mexican adults.Frontiers in endocrinology · 2026Article
- Machine learning-based prediction of prolonged length of stay in older patients with type 2 diabetes mellitus and cardiovascular disease.Frontiers in cardiovascular medicine · 2026Article
- Optimizing heart disease diagnosis with advanced machine learning models: a comparison of predictive performance.BMC cardiovascular disorders · 2025Article
- Pedalling towards better health: a randomised controlled trial of aerobic cycling to improve glycaemic control and quality of life in middle-aged men with type 2 diabetes.BMJ nutrition, prevention & health · 2025Article
Corrections and comments
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Authors and funding
16 authors.
Funding
Abstract
backgroundGuidelines and studies provide conflicting information on whether type 2 diabetes (T2D) should be considered a coronary heart disease risk (CHD) equivalent in older adults.
methodsWe synthesized participant-level data on 82,723 individuals aged ≥65 years from five prospective studies in two-stage meta-analyses. We estimated multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of T2D (presence versus absence) on a primary composite outcome defined as cardiovascular events or all-cause mortality. Secondary outcomes were the components of the composite. We evaluated CHD risk equivalence by comparing outcomes between individuals with T2D but no CHD versus CHD but no T2D.
resultsThe median age of participants was 71 years, 20% had T2D and 17% had CHD at baseline. A total of 29,474 participants (36%) experienced the composite outcome. Baseline T2D was associated with higher risk of cardiovascular events or all-cause mortality versus no T2D (HR 1.44, 95% CI [1.40-1.49]). The association was weaker in individuals aged ≥75 years versus 65-74 years (HR 1.32 [1.19-1.46] vs. 1.56 [1.50-1.62]; p-value for interaction = .032). Compared to individuals with CHD but no T2D, individuals with T2D but no CHD had a similar risk of the composite outcome (HR 0.95 [0.85-1.07]), but a lower risk of cardiovascular events (HR 0.76 [0.59-0.98]).
conclusionsT2D was associated with increased risk of cardiovascular events and all-cause mortality in older adults, but T2D without CHD conferred lower risk of cardiovascular events compared to CHD without T2D. Our results suggest that T2D should not be considered a CHD risk equivalent in older adults.
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