Evidence map›Paper›PMID 39465887›Full record

ArticleDevelopment (Cambridge, England)2024

Emerin preserves stem cell survival through maintenance of centrosome and nuclear lamina structure.

Samuel D Jones, Jack E B Miller, Madilynn M Amos, Julianna M Hernández, Katherine M Piaszynski, Pamela K Geyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Development (Cambridge, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Cells · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Samuel D JonesDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA 52242, USA.
Jack E B MillerDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA 52242, USA.
Madilynn M AmosDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA 52242, USA.
Julianna M HernándezDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA 52242, USA.
Katherine M PiaszynskiDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA 52242, USA.
Pamela K GeyerDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0001-9275-1407

Funding

The Role of LEM Domain Proteins in Nuclear FunctionR01GM087341 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K. · 2010 to 2022
$2.8M
NIGMS NIH HHS GM087341NIGMS NIH HHS R01 GM087341
6 · The paper itself

Abstract

Drosophila female germline stem cells (GSCs) complete asymmetric mitosis in the presence of an intact, but permeable, nuclear envelope and nuclear lamina (NL). This asymmetric division requires a modified centrosome cycle, wherein mitotic centrosomes with mature pericentriolar material (PCM) embed in the NL and interphase centrosomes with reduced PCM leave the NL. This centrosome cycle requires Emerin, an NL protein required for GSC survival and germ cell differentiation. In emerin mutants, interphase GSC centrosomes retain excess PCM, remain embedded in the NL and nucleate microtubule asters at positions of NL distortion. Here, we investigate the contributions of abnormal interphase centrosomes to GSC loss. Remarkably, reducing interphase PCM in emerin mutants rescues GSC survival and partially restores germ cell differentiation. Direct tests of the effects of abnormal centrosomes were achieved by expression of constitutively active Polo kinase to drive enlargement of interphase centrosomes in wild-type GSCs. Notably, these conditions failed to alter NL structure or decrease GSC survival. However, coupling enlarged interphase centrosomes with nuclear distortion promoted GSC loss. These studies establish that Emerin maintains centrosome structure to preserve stem cell survival.

Indexed as

Cell SurvivalCentrosomeDrosophila ProteinsMembrane ProteinsNuclear LaminaNuclear ProteinsStem CellsAnimalsCell DifferentiationDrosophila melanogasterFemaleGerm CellsInterphaseMitosisMutationProtein Serine-Threonine KinasesDrosophila ProteinsemerinMembrane ProteinsNuclear Proteinspolo protein, DrosophilaProtein Serine-Threonine KinasesAsymmetric divisionCentrosomeLaminLEM domainNuclear structureOtefinPolo

Identifiers

PMID39465887
PMCPMC11586520

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.