Evidence map›Paper›PMID 39465464›Full record

ArticleAIDS and behavior2025

South African Parents' and Grandparents' Perspectives on the Acceptability of Implant Delivery of Treatment to Young Children with HIV.

Imogen Hawley, Alejandro Baez, Fiona Scorgie, Lee Fairlie, Florence Mathebula, Mackenzie Leigh Cottrell, Leah M Johnson, Elizabeth T Montgomery

Abstract read
In one paragraph

Article in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Imogen HawleyWomen's Global Health Imperative, RTI International, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-5446-5976
Alejandro BaezWomen's Global Health Imperative, RTI International, Berkeley, CA, USA.
Fiona ScorgieWits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Lee FairlieWits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. lfairlie@wrhi.ac.za.
Florence MathebulaWits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Mackenzie Leigh CottrellUNC Eshelman School of Pharmacy, Chapel Hill, NC, USA.
Leah M JohnsonRTI International, Research Triangle Park, NC, USA.
Elizabeth T MontgomeryWomen's Global Health Imperative, RTI International, Berkeley, CA, USA.

Funding

Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
LA HIV Treatment in PediatricsR33AI149499 · NIAID · RESEARCH TRIANGLE INSTITUTE · PI COTTRELL, MACKENZIE, JOHNSON, LEAH · 2022 to 2024
$4.3M
LA HIV Treatment in PediatricsR61AI149499 · NIAID · RESEARCH TRIANGLE INSTITUTE · PI COTTRELL, MACKENZIE, JOHNSON, LEAH · 2020 to 2021
$2.0M
NIAID NIH HHS P30 AI050410NIAID NIH HHS R33 AI149499NIAID NIH HHS R61 AI149499
6 · The paper itself

Abstract

Children living with HIV (CLWH) face unique challenges with adherence to antiretroviral therapy. In South Africa, just over a third of children receiving antiretroviral therapy are virally suppressed. Long-acting, subcutaneous implants may improve outcomes in CLWH compared to current daily oral dosing regimens. Qualitative in-depth interviews and focus group discussions (FGD) were conducted with 50 caregivers of CLHW in Johannesburg, South Africa. Interviews and FGDs were audio-recorded and transcribed. Data were coded and analyzed using Dedoose v9 software and a thematic approach. Caregivers had generally positive impressions of the pediatric HIV treatment implant. They emphasized the advantages of a long-acting and discreet treatment option for CLWH. Cited advantages were perceived to have widespread impact on CLWH, their caregivers, and other social dynamics. Caregivers raised some concerns or uncertainties about the potential efficacy, side effects and safety of the implant. Future clinical testing and outreach efforts may address such concerns and mitigate potential misinformation about implants. This study indicates the need to develop long-acting, discreet, safe, and efficacious HIV treatment options for young children.

Indexed as

Anti-HIV AgentsGrandparentsHIV InfectionsParentsPatient Acceptance of Health CareAdultCaregiversChildChild, PreschoolFemaleFocus GroupsHumansInterviews as TopicMaleMedication AdherenceMiddle AgedAnti-HIV AgentsCaregiversHIV treatmentImplantsPediatric populationsQualitative end-user research

Identifiers

PMID39465464
PMCPMC11739182

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.