Evidence map›Paper›PMID 39465387›Full record

ArticleJournal of nanobiotechnology2024

Macrophage membrane-functionalized manganese dioxide nanomedicine for synergistic treatment of atherosclerosis by mitigating inflammatory storms and promoting cholesterol efflux.

Sijin Chen, Wenli Zhang, Chun Tang, Xiyue Rong, Yun Liu, Ying Luo, Lian Xu, Zhongsheng Xu, Junrui Wang, Yi Wang and 5 more

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Innovative nanoparticle strategies for treating oral cancers.Medical oncology (Northwood, London, England) · 2025
    Review
  13. Targeted drug delivery systems for atherosclerosis.Journal of nanobiotechnology · 2025
    Review
  14. Protective Effect of Carbon Dots Derived fromNanomaterials (Basel, Switzerland) · 2025
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sijin Chen *Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Wenli Zhang *Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Chun TangDepartment of Spine Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Xiyue RongDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Yun LiuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Ying LuoDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Lian XuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Zhongsheng XuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Junrui WangDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Yi WangDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Qianying DuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Bo LiuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Yu ZhangDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China.
Jia LiuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. 302956@hospital.cqmu.edu.cn.
Dajing GuoDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, China. guodaj@163.com.

Funding

Chongqing Municipal Education Commission CYB23199National Natural Science Foundation of China No. 82102063National Natural Science Foundation of China No. 82271970National Natural Science Foundation of China No. 82302164Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission cstc2021jcyj -msxmX0040
6 · The paper itself

Abstract

Atherosclerosis (AS) poses a significant threat to human life and health. However, conventional antiatherogenic medications exhibit insufficient targeting precision and restricted therapeutic effectiveness. Moreover, during the progression of AS, macrophages undergo polarization toward the proinflammatory M1 phenotype and generate reactive oxygen species (ROS) to accelerate the occurrence of inflammatory storms, and ingest excess lipids to form foam cells by inhibiting cholesterol efflux. In our study, we developed a macrophage membrane-functionalized hollow mesoporous manganese dioxide nanomedicine (Col@HMnO

Indexed as

AtherosclerosisCholesterolMacrophagesManganese CompoundsNanomedicineOxidesAnimalsCell MembraneDisease Models, AnimalFoam CellsHumansInflammationMaleMiceMice, Inbred C57BLRAW 264.7 CellsCholesterolManganese Compoundsmanganese dioxideOxidesReactive Oxygen SpeciesAtherosclerosisCholesterol effluxHollow mesoporous manganese dioxideInflammatory stormMacrophage membranes

Identifiers

PMID39465387
PMCPMC11514794

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.